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Abstract：
The use of genomic data in research and genomic information in clinical care is increasing as technologies advance and sequencing costs decrease. Using Rogers\' Diffusion of Innovation (DOI) theory as a framework we reviewed recent literature examining publics\' current knowledge of, attitude to, and motivation towards health-related genomics in clinical and research settings. The population of interest was described as \'publics\' to denote the heterogeneity of \'the public\'. Eligible studies were published in English between 2016-2022. We retrieved 1657 records, with 278 full-text reviewed against the eligibility criteria and concept definitions. In total, 99 articles were included in the review and descriptive numerical summaries were collated. Knowledge literature was categorized using deductive thematic analysis. For attitude and motivation, literature was coded using an analytic framework developed by the authors. There was wide variability in concept definition and measurement across studies. Overall, there was general positivity about genomics, with high awareness but little familiarity or factual knowledge. Publics had high expectations of genomics and perceived that it could provide them with information for their future. Only a few key attitudes were found to be important as motivators or barriers for participation in genomics; these were related to personal and clinical utility of the information. Context was often missing from studies, decreasing the utility of findings for implementation or public engagement. Future research would benefit by using theory-driven approaches to assess relevant publics\' knowledge and attitudes of specific contexts or applications to support genomic implementation and informed decision-making.
摘要：
随着技术的进步和测序成本的降低，基因组数据在研究中的使用和基因组信息在临床护理中的使用正在增加。使用罗杰斯的创新扩散（DOI）理论作为框架，我们回顾了最近的文献，研究公众的当前知识，态度,以及临床和研究环境中健康相关基因组学的动机。感兴趣的人群被描述为“公众”，以表示“公众”的异质性。符合条件的研究在2016-2022年间以英文发表。我们检索了1657条记录,根据资格标准和概念定义审查了278份全文。总的来说,审查中包括99篇文章，并整理了描述性数字摘要。使用演绎主题分析对知识文献进行分类。为了态度和动机，文献是使用作者开发的分析框架编码的。研究中概念定义和测量存在很大差异。总的来说,对基因组学有普遍的肯定，有很高的意识，但很少熟悉或事实知识。公众对基因组学有很高的期望，并认为它可以为他们的未来提供信息。发现只有少数关键态度作为参与基因组学的动机或障碍很重要；这些与信息的个人和临床效用有关。研究中经常缺少上下文，降低调查结果对实施或公众参与的效用。未来的研究将受益于使用理论驱动的方法来评估相关公众对特定背景或应用的知识和态度，以支持基因组实施和知情决策。
