PDF(Pubmed)
Abstract：
A systematic review and meta-analysis were performed to identify if there is a subset of patients with POI who are more likely to show follicular growth after ovarian fragmentation for follicular activation (OFFA) or in vitro activation (IVA). Five studies met inclusion criteria for meta-analysis with a total of 164 patients. Forty-three patients showed follicle development (26.21%). Of those, the pregnancy rate was 35.58% (11/43) and the live birth rate was 20.93% (9/43). Our meta-analysis showed that age was not associated with follicle growth. However, lower baseline FSH, lower duration of amenorrhea/diagnosis, and presence of follicles remaining in biopsy were statistically significant for follicle development. Patients with basal characteristics mentioned before may have more chances to show follicle growth after OFFA or IVA. Taking into account that approximately 20% of patients with follicle growth had live birth, these results are very promising. Given the overall certainty of evidence, future studies are needed to confirm said results.
摘要：
进行了系统评价和荟萃分析，以确定是否有一部分POI患者在卵巢破裂后更有可能显示卵泡生长，以进行卵泡激活（OFFA）或体外激活（IVA）。5项研究符合荟萃分析的纳入标准，共有164名患者。43例患者表现为卵泡发育(26.21%)。其中,妊娠率为35.58%(11/43),活产率为20.93%(9/43)。我们的荟萃分析显示年龄与卵泡生长无关。然而,较低基线FSH,闭经/诊断持续时间较低，活检中残留的卵泡对卵泡发育有统计学意义。先前提到的具有基础特征的患者在OFFA或IVA后可能有更多机会显示卵泡生长。考虑到大约20%的卵泡生长患者有活产，这些结果非常有希望。鉴于证据的总体确定性，未来的研究需要证实上述结果.
