PDF(Pubmed)
Abstract：
Several clinical and preclinical studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly aspirin, reduce the incidence of various cancer types. However, there is still a lack of literature evaluating the overall association between multiple cancer morbidities and NSAIDs. Thus, we conducted an umbrella review to evaluate the quality of evidence, validity, and biases of the existing systematic reviews and meta-analyses on the relationships between NSAIDS and multiple tumor incidence outcomes. We found that NSAIDs might be associated with a decreased risk of several cancers, including the central nervous system, breast, esophageal, gastric, head and neck, hepatocellular, cholangiocarcinoma, colorectal, endometrial, lung, ovary, prostate, and pancreatic cancers, but regular intake of any dose of non-aspirin NSAIDs (NA-NSAIDs) could increase the incidence of kidney cancer. However, most of included studies are evaluated as low quality according to our evidence assessment. Furthermore, due to the potential side effects, such as hemorrhage, digestive symptoms and peptic ulcer, it is still not recommend to use NSAIDs regularly to prevent cancers.
摘要：
一些临床和临床前研究表明，非甾体抗炎药（NSAIDs），尤其是阿司匹林,减少各种癌症的发病率。然而,目前仍缺乏评估多种癌症发病率与NSAIDs之间总体关联的文献.因此，我们进行了全面审查，以评估证据的质量，有效性，以及现有系统综述和荟萃分析对NSAIDS与多种肿瘤发病率结局之间关系的偏见。我们发现NSAIDs可能与几种癌症的风险降低有关，包括中枢神经系统,乳房,食道,胃,头部和颈部,肝细胞，胆管癌,结直肠,子宫内膜,肺，子房,前列腺,和胰腺癌，但定期摄入任何剂量的非阿司匹林NSAIDs(NA-NSAIDs)均可增加肾癌的发病率.然而,根据我们的证据评估,大多数纳入的研究被评估为低质量.此外，由于潜在的副作用，比如出血，消化症状和消化性溃疡,仍然不建议定期使用NSAIDs来预防癌症。
