Abstract：
Changes in circadian rhythms have been observed in patients with chronic kidney disease (CKD), and evidence suggests that these changes can have a negative impact on health. This study aimed to investigate the existence of hemodialysis-induced chronodisruption, the chronotype distribution, and their association with sleep quality and quality of life (QoL). This was a cross-sectional study that enrolled 165 patients (mean age: 51.1 ± 12.5 y, 60.6% male) undergoing hemodialysis from three local units. The following instruments were used: the Morning-Eveningness Questionnaire (MEQ); a modified version of the Munich Chronotype Questionnaire (MCQT) to estimate hemodialysis-induced chronodisruption (HIC); the Kidney Disease QoL Short Form (KDQOL-SF); the Epworth Sleepiness Scale (ESS); the Pittsburgh Sleep Quality Index (PSQI) and the 10-Cognitive Screener (10-CS). HIC was present in 40.6% of CKD patients. Morning chronotype was prevalent in CKD patients (69%) compared to evening-type (17.1%) and significantly different from a paired sample from the general population (p < 0.001). HIC and chronotype were associated with different domains of QoL but not with sleep quality. This study suggests that there is a HIC and that morning chronotype is associated with CKD patients undergoing hemodialysis, with implications for QoL.
摘要：
在慢性肾脏病（CKD）患者中观察到昼夜节律的变化，证据表明这些变化会对健康产生负面影响。这项研究旨在探讨血液透析引起的慢性中断的存在，时间型分布，以及它们与睡眠质量和生活质量(QoL)的关系。这是一项横断面研究，纳入了165名患者（平均年龄：51.1±12.5岁，60.6%的男性)从三个地方单位接受血液透析。使用以下工具：早晨-均匀性问卷（MEQ）；慕尼黑时态问卷（MCQT）的修订版，用于评估血液透析引起的时间破坏（HIC）；肾脏疾病QoL简表（KDQOL-SF）；Epworth嗜睡量表（ESS）；匹兹堡睡眠质量指数（PI）和10-认知SQener（10-CS）。HIC存在于40.6%的CKD患者中。与晚间型（17.1％）相比，晨间型在CKD患者中普遍存在（69％），并且与普通人群的配对样本显着不同（p<0.001）。HIC和时间型与QoL的不同领域相关，但与睡眠质量无关。这项研究表明，有一个HIC和早晨型与CKD患者进行血液透析有关，对QoL的影响。
