METHODS: A systematic review on literature published until December 2022 on imaging characteristics of MTTs was performed. Based on that, we conducted a retrospective, monocentric analysis of patients with histopathologically proven MTTs from our department. Explorative data analysis was performed.
RESULTS: Initially, 29 studies on 34 patients (31.42 ± 22.6 years, 12 female) were evaluated: Literature described primary MTTs as huge, lobulated tumours (108 ± 99.3 mm) with central necrosis (56% [19/34]), low T1w (81% [17/21]), high T2w signal (90% [19/21]) and inhomogeneous enhancement on MRI (54% [7/13]). Analysis of 16 patients (48.9 ± 13.8 years; 9 female) from our institution revealed comparable results: primary MTTs showed large, lobulated masses (118 mm ± 64.9) with necrotic areas (92% [11/12]). MRI revealed low T1w (100% [7/7]), high T2w signal (100% [7/7]) and inhomogeneous enhancement (86% [6/7]). Local recurrences and soft-tissue metastases mimicked these features, while nonsoft-tissue metastases appeared unspecific.
CONCLUSIONS: MTTs show characteristic features on CT and MRI. However, these do not allow a reliable differentiation between MTTs and other MPNSTs based on imaging alone. Therefore, additional histopathological analysis is required.
CONCLUSIONS: This largest published systematic analysis on MTT imaging revealed typical but unspecific imaging features that do not allow a reliable, imaging-based differentiation between MTTs and other MPNSTs. Hence, additional histopathological analysis remains essential.
方法:对2022年12月之前发表的关于MTT影像学特征的文献进行了系统评价。基于此,我们做了一个回顾,来自我们部门的经组织病理学证实的MTT患者的单中心分析。进行探索性数据分析。
结果:最初,对34例患者进行29项研究(31.42±22.6年,12名女性)进行了评估:文献描述了主要的MTT巨大,小叶性肿瘤(108±99.3mm)伴中央坏死(56%[19/34]),低T1w(81%[17/21]),高T2w信号(90%[19/21])和MRI不均匀增强(54%[7/13])。对我们机构的16例患者(48.9±13.8岁;9名女性)的分析显示出可比的结果:原发性MTT显示大,分叶肿块(118mm±64.9),坏死面积(92%[11/12])。MRI显示低T1w(100%[7/7]),高T2w信号(100%[7/7])和不均匀增强(86%[6/7])。局部复发和软组织转移模仿了这些特征,而非软组织转移似乎没有特异性。
结论:MTT在CT和MRI上表现出特征性特征。然而,这些不允许MTT和其他MPNST之间的可靠区分仅基于成像.因此,需要额外的组织病理学分析。
结论:这项已发表的关于MTT成像的最大系统分析揭示了典型但非特异性的成像特征,基于成像的MTT和其他MPNST之间的区别。因此,额外的组织病理学分析仍然至关重要。