PDF(Pubmed)
Abstract：
Human T-cell leukemia virus type 1 (HTLV-1) can cause HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Current treatment options for HAM/TSP are limited. We present a woman with rapidly-progressive HAM/TSP with significant, sustained clinical improvement following initiation of mycophenolate mofetil (MMA). Peripheral blood mononuclear cells from the patient, her asymptomatic carrier husband and eight healthy controls were isolated. Frequencies of T-cell populations upon exposure to low and high MMA concentrations and differences in proliferation were analyzed using flow cytometry and a CSFE-proliferation assay. Characterization of T-cell function and proliferation showed higher levels of GranzymeB in HTLV-1+ donors. The improvement and stability of symptoms in this patient with HAM/TSP following MMA initiation requires further study as a potential treatment for HAM/TSP.
摘要：
人T细胞白血病病毒1型(HTLV-1)可引起HTLV-1相关性脊髓病/热带痉挛性轻瘫(HAM/TSP)。HAM/TSP的当前治疗选择有限。我们提出了一个女性快速进展的HAM/TSP与显著，持续的临床改善后开始霉酚酸酯（MMA）。患者外周血单核细胞,她的无症状携带者丈夫和8名健康对照者被隔离。使用流式细胞术和CSFE增殖测定分析了暴露于低和高MMA浓度时T细胞群的频率和增殖差异。T细胞功能和增殖的表征显示HTLV-1+供体中更高水平的GranzymeB。MMA开始后，该患者HAM/TSP症状的改善和稳定性需要进一步研究作为HAM/TSP的潜在治疗方法。
