Abstract：
Extra virgin olive oil (EVOO) is thought to contribute to neuroprotection and, thus, may influence pain symptoms experienced by adults with demyelination-related trigeminal neuralgia (TN). This study aimed to determine the feasibility of daily intake of EVOO and its potential to alleviate facial pain of TN. Adults, self-reporting as female and affected by TN, were enrolled in a 16-week nonblinded, parallel study. After a 4-week baseline, participants were randomized to 60 mL/day EVOO or control (usual diet and no supplemental EVOO) for 12 weeks. Participants completed a daily questionnaire on pain intensity and compliance, the Penn Facial Pain Scale weekly, the 36-Item Short Form Survey monthly, and dietary assessment during baseline and intervention. Participants (n = 52; 53.3 ± 12.9 years) were recruited nationally; 42 completed the study. The EVOO group, with 90% intake compliance, showed significant decreases in the Penn Facial Pain Scale items of interference with general function, interference with orofacial function, and severity of pain from baseline, whereas the control group showed no improvements. EVOO benefit, compared with control, trended for the interference with orofacial function (P = .05). The 36-Item Short Form Survey items of role limitations resulting from emotional problems and role limitations from physical health favored EVOO. The EVOO group significantly improved their Healthy Eating Index 2015 component scores of fatty acids (primarily from increased oleic acid), sodium, and refined grains. EVOO intake of 60 mL/day was feasible for participants experiencing TN and may mitigate pain and improve quality of life. This trial was registered at clinicaltrials.gov (NCT05032573).
摘要：
特级初榨橄榄油（EVOO）被认为有助于神经保护，因此，可能会影响成人脱髓鞘相关三叉神经痛（TN）的疼痛症状。本研究旨在确定每日摄入EVOO的可行性及其缓解TN面部疼痛的潜力。成人,自我报告为女性，受TN影响，参加了为期16周的非盲，平行研究。经过4周的基线，参与者被随机分为60mL/天的EVOO组或对照组(常规饮食,无补充EVOO)组,共12周.参与者完成了关于疼痛强度和依从性的每日问卷，宾夕法尼亚大学每周的面部疼痛量表，每月36项简短表格调查，以及基线和干预期间的饮食评估。在全国范围内招募参与者（n=52；53.3±12.9岁）；42人完成了研究。EVOO组,90%的摄入量合规，Penn面部疼痛量表对一般功能的干扰显着减少，干扰口面功能，从基线开始疼痛的严重程度，而对照组无改善。EVOO的好处,与对照相比，趋势为干扰口面功能（P=.05）。由情绪问题引起的角色限制和身体健康引起的角色限制的36项简短形式调查项目对EVOO有利。EVOO组显着提高了他们的健康饮食指数2015脂肪酸成分得分（主要来自增加的油酸），钠,和精致的谷物。对于患有TN的参与者，每天摄入60mL的EVOO是可行的，并且可以减轻疼痛并改善生活质量。该试验在clinicaltrials.gov(NCT05032573)注册。
