Abstract：
Studies on cancer loci by use of twin data reveal sources of variation in risk. The Nordic twin and cancer registries contain the largest cohort of population representative twins ever studied with more than median 40 years of follow-up. This article considers findings that show influences on familial risk and demonstrates the strengths of the matched case co-twin design for unraveling important risk factors of cancers. Studies using twin data will expectedly continue to provide insights into cancer epidemiology and genetics for the benefit of prevention and treatment.
摘要：
通过使用双胞胎数据对癌症基因座的研究揭示了风险变化的来源。北欧双胞胎和癌症登记处包含有史以来最大的人口代表性双胞胎队列，随访时间中位数超过40年。本文考虑了显示对家族风险的影响的发现，并证明了匹配的共同双胞胎设计在揭示癌症重要风险因素方面的优势。使用双胞胎数据的研究将有望继续提供对癌症流行病学和遗传学的见解，以促进预防和治疗。
