PDF(Pubmed)
Abstract：
Marine-derived fungi of the genus Trichoderma have been surveyed for pharmaceuticals and agrochemicals since 1993, with various new secondary metabolites being characterized from the strains of marine animal, plant, sediment, and water origin. Chemical structures and biological activities of these metabolites are comprehensively reviewed herein up to the end of 2022 (covering 30 years). More than 70 strains that belong to at least 18 known Trichoderma species have been chemically investigated during this period. As a result, 445 new metabolites, including terpenes, steroids, polyketides, peptides, alkaloids, and others, have been identified, with over a half possessing antimicroalgal, zooplankton-toxic, antibacterial, antifungal, cytotoxic, anti-inflammatory, and other activities. The research is highlighted by the molecular diversity and antimicroalgal potency of terpenes and steroids. In addition, metabolic relevance along with co-culture induction in the production of new compounds is also concluded. Trichoderma strains of marine origin can transform and degrade heterogeneous molecules, but these functions need further exploration.
摘要：
自1993年以来，已对木霉属的海洋来源真菌进行了药物和农用化学品调查，并从海洋动物菌株中表征了各种新的次级代谢产物，植物,沉积物,水的起源。到2022年底（覆盖30年），本文对这些代谢物的化学结构和生物活性进行了全面审查。在此期间，对至少18种已知木霉属物种的70多种菌株进行了化学研究。因此,445种新的代谢产物,包括萜烯,类固醇,聚酮化合物,肽，生物碱，和其他人,已经被确认,超过一半拥有抗微生物藻类，浮游动物-有毒,抗菌，抗真菌药,细胞毒性，抗炎,和其他活动。该研究突出了萜烯和类固醇的分子多样性和抗微生物效力。此外,还总结了新化合物生产中的代谢相关性以及共培养诱导。海洋来源的木霉菌株可以转化和降解异质分子，但是这些功能需要进一步探索。
