PDF(Pubmed)
Abstract：
OBJECTIVE: Intratympanic injection of corticosteroids (ITC) and gentamicin therapy (ITG) are widely used treatments for vertigo in Meniere\'s disease (MD). Even though studies show good results after cochlea implantation (CI) in MD patients when compared to non-MD groups, there is no indication on the effect of ITC and ITG prior to CI on hearing after CI. This study compares the post-operative hearing of CI patients with and without MD and patients who have received ITG or ITC prior to CI.
METHODS: In a retrospective case control study, adult patients with MD who received CI from 2002 till 2021 were compared to a matched control group of CI patients without MD. Patients with prior ITC/ITG were extracted from MD group. Pre-operative audiological results were measured and trends across post-operative monosyllabic word recognition score at 65 decibels (WRS65CI) at switch-on, 3-6 months, 1 year and last yearly value were analyzed across all groups.
RESULTS: 28 MD ears were compared with 33 control ears. From MD ears 9 had received ITG and 6 ITC prior to CI. WRS65CI increased significantly with time within MD and control groups, but no difference in WRS65CI was found between these 2 groups. ITG ears showed fluctuating WRS65CI after CI with no change across time, while ITC ears showed significant increase in trend of WRS65CI values across time.
CONCLUSIONS: MD and non-MD patients showed comparable hearing results after CI. Prior ITC might positively influence hearing preservation after CI in MD patients whereas ITG group showed fluctuating hearing.
METHODS: In a retrospective case control study, adult patients with MD who received CI from 2002 till 2021 were compared to a matched control group of CI patients without MD. Patients with prior ITC/ITG were extracted from MD group. Pre-operative audiological results were measured and trends across post-operative monosyllabic word recognition score at 65 decibels (WRS65CI) at switch-on, 3-6 months, 1 year and last yearly value were analyzed across all groups.
RESULTS: 28 MD ears were compared with 33 control ears. From MD ears 9 had received ITG and 6 ITC prior to CI. WRS65CI increased significantly with time within MD and control groups, but no difference in WRS65CI was found between these 2 groups. ITG ears showed fluctuating WRS65CI after CI with no change across time, while ITC ears showed significant increase in trend of WRS65CI values across time.
CONCLUSIONS: MD and non-MD patients showed comparable hearing results after CI. Prior ITC might positively influence hearing preservation after CI in MD patients whereas ITG group showed fluctuating hearing.
摘要：
目的：鼓室内注射糖皮质激素（ITC）和庆大霉素治疗（ITG）是治疗梅尼埃病（MD）眩晕的广泛应用方法。尽管研究表明，与非MD组相比，MD患者在耳蜗植入（CI）后取得了良好的结果，没有迹象表明ITC和ITG在toCI之前对听力的影响。这项研究比较了患有和不患有MD的CI患者以及在toCI之前接受ITG或ITC的患者的术后听力。
方法：在一项回顾性病例对照研究中，从2002年到2021年接受CI的成年MD患者与无MD的CI患者的匹配对照组进行比较.从MD组中提取具有先前ITC/ITG的患者。测量了术前听力学结果，并在打开时65分贝（WRS65CI）的术后单音节单词识别得分的趋势，3-6个月,对所有组的1年和最后一年的值进行分析。
结果：将28只MD耳朵与33只对照耳朵进行了比较。来自MD的耳朵9在toCI之前接受了ITG和6ITC。WRS65CI在MD组和对照组随时间显著增加,但两组间WRS65CI无差异。ITG耳朵显示WRS65CI后波动，随时间无变化，而ITC耳部WRS65CI值随时间呈显著上升趋势。
结论：MD和非MD患者在CI后表现出相当的听力结果。在MD患者中，先前的ITC可能会对CI后的听力保护产生积极影响，而ITG组表现出听力波动。
方法：在一项回顾性病例对照研究中，从2002年到2021年接受CI的成年MD患者与无MD的CI患者的匹配对照组进行比较.从MD组中提取具有先前ITC/ITG的患者。测量了术前听力学结果，并在打开时65分贝（WRS65CI）的术后单音节单词识别得分的趋势，3-6个月,对所有组的1年和最后一年的值进行分析。
结果：将28只MD耳朵与33只对照耳朵进行了比较。来自MD的耳朵9在toCI之前接受了ITG和6ITC。WRS65CI在MD组和对照组随时间显著增加,但两组间WRS65CI无差异。ITG耳朵显示WRS65CI后波动，随时间无变化，而ITC耳部WRS65CI值随时间呈显著上升趋势。
结论：MD和非MD患者在CI后表现出相当的听力结果。在MD患者中，先前的ITC可能会对CI后的听力保护产生积极影响，而ITG组表现出听力波动。
