Abstract：
OBJECTIVE: To investigate midbrain growth, including corpus callusum (CC) and cerebellar vermis (CV) and cortical development in late fetal growth restricted (FGR) subclassified according to the umbilical vein blood flow (UVBF) values.
METHODS: This was a prospective study on singleton fetuses late FGR with abnormal placental cerebral ratio (PCR). FGR fetuses were further subdivided into normal (≥fifth centile) and abnormal (RESULTS: The study cohort included 60 late FGR, 31 with normal UVBF/AC and 29 with abnormal UVBF/AC values. The latter group showed significant differences in CC (median (interquartile range (IQR) normal 0.96 (0.73-1.16) vs. abnormal UVBF/AC 0.60 (0.47-0.87); p<0.0001)), CV (normal 1.04 (0.75-1.26) vs. abnormal UVBF (AC 0.76 (0.62-1.18)); p=0.0319), SF (normal 0.83 (0.74-0.93) vs. abnormal UVBF/AC 0.56 (0.46-0.68); p<0.0001), POF (normal 0.80 (0.71-0.90) vs. abnormal UVBF/AC l 0.49 (0.39-0.90); p≤0.0072) and CF (normal 0.83 (0.56-1.01) vs. abnormal UVBF/AC 0.72 (0.53-0.80); p<0.029).
CONCLUSIONS: Late onset FGR fetuses with of reduced umbilical vein flow showed shorter CC and CV length and a delayed cortical development when compared to those with normal umbilical vein hemodynamics. These findings support the existence of a link between abnormal brain development and changes in umbilical vein circulation.
METHODS: This was a prospective study on singleton fetuses late FGR with abnormal placental cerebral ratio (PCR). FGR fetuses were further subdivided into normal (≥fifth centile) and abnormal (
CONCLUSIONS: Late onset FGR fetuses with of reduced umbilical vein flow showed shorter CC and CV length and a delayed cortical development when compared to those with normal umbilical vein hemodynamics. These findings support the existence of a link between abnormal brain development and changes in umbilical vein circulation.
摘要：
目的：研究中脑生长，根据脐静脉血流量（UVBF）值进行细分，包括call体（CC）和小脑疣（CV）和晚期胎儿生长受限（FGR）的皮质发育。
方法：这是一项对胎盘大脑比率异常的单胎胎儿晚期FGR（PCR）的前瞻性研究。FGR胎儿进一步细分为正常（≥第五百分位）和异常（<第五百分位）UVBF血流量校正为AC（UVBF/AC），在妊娠33-34周进行神经超声检查，以评估CC和CV长度以及Sylvian裂（SF）的深度，顶枕骨（POF）和钙质裂（CF）。神经超声检查变量针对胎儿头围大小进行归一化。
结果：研究队列包括60个晚期FGR，31的UVBF/AC值正常，29的UVBF/AC值异常。后一组在CC（中位数（四分位距（IQR）正常0.96（0.73-1.16）与异常UVBF/AC0.60（0.47-0.87）；p<0.0001）），CV（正常1.04（0.75-1.26）与异常UVBF（AC0.76（0.62-1.18）；p=0.0319），SF（正常0.83（0.74-0.93）与异常UVBF/AC0.56（0.46-0.68）；p<0.0001），POF（正常0.80（0.71-0.90）与异常UVBF/ACl0.49（0.39-0.90）；p≤0.0072）和CF（正常0.83（0.56-1.01）与异常UVBF/AC0.72（0.53-0.80）；p<0.029）。
结论：与脐静脉血流动力学正常的胎儿相比，脐静脉血流减少的晚发性FGR胎儿的CC和CV长度较短，皮质发育延迟。这些发现支持大脑发育异常与脐静脉循环变化之间存在联系。
方法：这是一项对胎盘大脑比率异常的单胎胎儿晚期FGR（PCR）的前瞻性研究。FGR胎儿进一步细分为正常（≥第五百分位）和异常（<第五百分位）UVBF血流量校正为AC（UVBF/AC），在妊娠33-34周进行神经超声检查，以评估CC和CV长度以及Sylvian裂（SF）的深度，顶枕骨（POF）和钙质裂（CF）。神经超声检查变量针对胎儿头围大小进行归一化。
结果：研究队列包括60个晚期FGR，31的UVBF/AC值正常，29的UVBF/AC值异常。后一组在CC（中位数（四分位距（IQR）正常0.96（0.73-1.16）与异常UVBF/AC0.60（0.47-0.87）；p<0.0001）），CV（正常1.04（0.75-1.26）与异常UVBF（AC0.76（0.62-1.18）；p=0.0319），SF（正常0.83（0.74-0.93）与异常UVBF/AC0.56（0.46-0.68）；p<0.0001），POF（正常0.80（0.71-0.90）与异常UVBF/ACl0.49（0.39-0.90）；p≤0.0072）和CF（正常0.83（0.56-1.01）与异常UVBF/AC0.72（0.53-0.80）；p<0.029）。
结论：与脐静脉血流动力学正常的胎儿相比，脐静脉血流减少的晚发性FGR胎儿的CC和CV长度较短，皮质发育延迟。这些发现支持大脑发育异常与脐静脉循环变化之间存在联系。
