Abstract：
Hernia surgery is a widely performed procedure, and the use of a polypropylene mesh is considered the standard approach. However, the mesh often leads to complications, including the development of scar tissue that wraps around the mesh and causes it to shrink. Consequently, there is a need to investigate the relationship between the mesh and scar formation as well as to develop a hernia mesh that can prevent fibrosis. In this study, three different commercial polypropylene hernia meshes were examined to explore the connection between the fabric structure and mechanical properties. In vitro dynamic culture was used to investigate the mechanism by which the mechanical properties of the mesh in a dynamic environment affect cell differentiation. Additionally, electrospinning was employed to create polycaprolactone spider-silk-like fiber mats to achieve mechanical energy dissipation in dynamic conditions. These fiber mats were then combined with the preferred hernia mesh. The results demonstrated that the composite mesh could reduce the activation of fibroblast mechanical signaling pathways and inhibit its differentiation into myofibroblasts in dynamic environments.
摘要：
疝手术是一种广泛进行的手术，和聚丙烯网的使用被认为是标准的方法。然而,网状物经常导致并发症，包括包裹在网状物周围并导致其收缩的疤痕组织的发展。因此,有必要研究网片和瘢痕形成之间的关系，以及开发一种可以预防纤维化的疝网片。在这项研究中,研究了三种不同的商业聚丙烯疝网，以探索织物结构和机械性能之间的联系。体外动态培养用于研究动态环境中网状物的机械特性影响细胞分化的机制。此外,采用静电纺丝技术制造聚己内酯蜘蛛丝状纤维垫，以实现动态条件下的机械能耗散。然后将这些纤维垫与优选的疝网片组合。结果表明，复合网片可以减少成纤维细胞机械信号通路的激活，抑制其在动态环境中分化为肌成纤维细胞。
