Abstract：
Shoulder pain and disabilities are prevalent issues among the elderly population, with rotator cuff tear (RCT) being one of the leading causes. Although surgical treatment has shown some success, high postoperative retear rates remain a great challenge, particularly in elderly patients. Aging-related degeneration of muscle, tendon, tendon-to-bone enthesis, and bone plays a critical role in the development and prognosis of RCT. Studies have demonstrated that aging worsens muscle atrophy and fatty infiltration, alters tendon structure and biomechanical properties, exacerbates enthesis degeneration, and reduces bone density. Although recent researches have contributed to understanding the pathophysiological mechanisms of aging-related RCT, a comprehensive systematic review of this topic is still lacking. Therefore, this article aims to present a review of the pathophysiological changes and their clinical significance, as well as the molecular mechanisms underlying aging-related RCT, with the goal of shedding light on new therapeutic approaches to reduce the occurrence of aging-related RCT and improve postoperative prognosis in elderly patients.
摘要：
肩痛和残疾是老年人群普遍存在的问题,肩袖撕裂（RCT）是主要原因之一。虽然手术治疗取得了一定的成功,高术后再撕裂率仍然是一个巨大的挑战，尤其是老年患者。衰老相关的肌肉退化，肌腱,腱-骨发生,骨在RCT的发展和预后中起着至关重要的作用。研究表明，衰老会加剧肌肉萎缩和脂肪浸润，改变肌腱结构和生物力学特性，加剧了变性，降低骨密度.尽管最近的研究有助于理解衰老相关RCT的病理生理机制，对这一主题仍然缺乏全面系统的审查。因此,本文就其病理生理变化及其临床意义作一综述,以及与衰老相关的RCT的分子机制，目的是探讨新的治疗方法，以减少与衰老相关的RCT的发生并改善老年患者的术后预后。
