Abstract：
OBJECTIVE: Dysthyroid optic neuropathy (DON) leads to vision loss. This study aimed to investigate a new method that can directly evaluate the change in muscle cone inner volume (MCIV) and distinguish DON orbits from non-DONs.
METHODS: This study included 54 patients (108 orbits) who were diagnosed with thyroid eye disease and treated at the Beijing Tongren Hospital between December 2019 and September 2021. The extraocular muscle volume (EOMV), orbital fat volume (OFV), and bony orbit volume (BOV) of the patients were measured using three-dimensional reconstruction. MCIV was measured using artificially defined boundaries. The associations between these volumes and clinical indicators were studied, and the diagnostic efficacy of these volumes for DON was described using receiver operating characteristic (ROC) curves.
RESULTS: The ROC curve showed that the area under the curve of MCIV/BOV (%) combined with EOMV/BOV (%) reached 0.862 (p < 0.001), with a sensitivity of 85.7% and a specificity of 76.1%.
CONCLUSIONS: The combination of MCIV/BOV (%) and EOMV/BOV (%) is a good indicator for the diagnosis of DON, which aids in the early detection and intervention of DON.
METHODS: This study included 54 patients (108 orbits) who were diagnosed with thyroid eye disease and treated at the Beijing Tongren Hospital between December 2019 and September 2021. The extraocular muscle volume (EOMV), orbital fat volume (OFV), and bony orbit volume (BOV) of the patients were measured using three-dimensional reconstruction. MCIV was measured using artificially defined boundaries. The associations between these volumes and clinical indicators were studied, and the diagnostic efficacy of these volumes for DON was described using receiver operating characteristic (ROC) curves.
RESULTS: The ROC curve showed that the area under the curve of MCIV/BOV (%) combined with EOMV/BOV (%) reached 0.862 (p < 0.001), with a sensitivity of 85.7% and a specificity of 76.1%.
CONCLUSIONS: The combination of MCIV/BOV (%) and EOMV/BOV (%) is a good indicator for the diagnosis of DON, which aids in the early detection and intervention of DON.
摘要：
目的：甲状腺功能异常视神经病变（DON）导致视力丧失。这项研究旨在研究一种新的方法，可以直接评估肌肉锥内体积（MCIV）的变化，并区分DON轨道和非DON。
方法：本研究纳入北京同仁医院2019年12月至2021年9月收治的54例（108眼眶）甲状腺眼病患者。眼外肌体积（EOMV），眼眶脂肪体积(OFV),使用三维重建测量患者的骨眶体积（BOV）。使用人工定义的边界测量MCIV。研究了这些体积与临床指标之间的关联，使用受试者工作特征（ROC）曲线描述了这些体积对DON的诊断功效。
结果：ROC曲线显示MCIV/BOV（％）结合EOMV/BOV（％）的曲线下面积达到0.862（p<0.001），敏感性为85.7%，特异性为76.1%。
结论：MCIV/BOV（％）和EOMV/BOV（％）的组合是诊断DON的良好指标，这有助于早期发现和干预DON。
方法：本研究纳入北京同仁医院2019年12月至2021年9月收治的54例（108眼眶）甲状腺眼病患者。眼外肌体积（EOMV），眼眶脂肪体积(OFV),使用三维重建测量患者的骨眶体积（BOV）。使用人工定义的边界测量MCIV。研究了这些体积与临床指标之间的关联，使用受试者工作特征（ROC）曲线描述了这些体积对DON的诊断功效。
结果：ROC曲线显示MCIV/BOV（％）结合EOMV/BOV（％）的曲线下面积达到0.862（p<0.001），敏感性为85.7%，特异性为76.1%。
结论：MCIV/BOV（％）和EOMV/BOV（％）的组合是诊断DON的良好指标，这有助于早期发现和干预DON。
