The working group was composed of pediatric gastroenterologists, adult gastroenterologists, allergists/immunologists, and pathologists. An extensive electronic literature search of the MEDLINE, EMBASE, and Cochrane databases was conducted up to February 2022. General methodology was used in the formulation of recommendations according to the Appraisal of Guidelines for Research and Evaluation (AGREE) II and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to meet current standards of evidence assessment.
The guidelines provide information on the current concept of non-EoE EGIDs, disease pathogenesis, epidemiology, clinical manifestations, diagnostic and disease surveillance procedures, and current treatment options. Thirty-four statements based on available evidence and 41 recommendations based on expert opinion and best clinical practices were developed.
Non-EoE EGIDs literature is limited in scope and depth, making clear recommendations difficult. These consensus-based clinical practice guidelines are intended to assist clinicians caring for children affected by non-EoE EGIDs and to facilitate high-quality randomized controlled trials of various treatment modalities using standardized, uniform disease definitions.
工作组由儿科胃肠病学家组成,成人胃肠病学家,过敏/免疫学家,和病理学家。对MEDLINE进行广泛的电子文献检索,EMBASE,和Cochrane数据库进行到2022年2月。根据《研究和评估指南》(AGREE)II和《建议评估分级》,在制定建议时使用了一般方法。开发和评估(等级)系统,以满足当前的证据评估标准。
指南提供了关于当前非EoEEGID概念的信息,疾病的发病机理,流行病学,临床表现,诊断和疾病监测程序,和目前的治疗选择。根据现有证据制定了34项声明,根据专家意见和最佳临床实践制定了41项建议。
非EoEEGID文献的范围和深度有限,提出明确的建议是困难的。这些基于共识的临床实践指南旨在帮助临床医生照顾受非EoEEGID影响的儿童,并促进使用标准化的各种治疗方式的高质量随机对照试验。统一的疾病定义。