Abstract：
The Research Institute for Fragrance Materials (RIFM) and Creme Global Cremeglobal.com partnered to develop an aggregate exposure model for fragrance ingredients. The model provides a realistic estimate of the total exposure of fragrance ingredients to individuals across a population. The Threshold of Toxicological Concern (TTC) and Dermal Sensitization Threshold (DST) were used to demonstrate the magnitude of low exposure to fragrance materials. The total chronic systemic, inhalation, and dermal 95th percentile exposures on approximately 3000 fragrance ingredients in RIFM\'s inventory were compared to their respective TTC or DST. Additionally, representative fragrance ingredients were randomly selected and analyzed for exposure distribution by product type (i.e., cosmetic/personal care, household care, oral care, and air care) and route of exposure. It was found that 76 % of fragrance ingredients fall below their respective TTC limits when compared to 95th percentile systemic exposure, while 99 % are below inhalation TTC limits. The lowest 95th percentile aggregate exposure by product type was from household care products, then air care, and oral care products. The highest exposure was from personal care/cosmetic products. The volume of use for most fragrance ingredients (63 %) was <1 metric ton, estimating that environmental exposure to fragrance ingredients is likely low.
摘要：
香料材料研究所（RIFM）和CremeGlobal（Cremeglobal.com）合作开发了香料成分的聚合暴露模型。该模型提供了对整个人群中香料成分对个体的总暴露量的现实估计。使用毒理学关注阈值（TTC）和皮肤致敏阈值（DST）来证明对香料材料的低暴露程度。总的慢性全身性，吸入,将RIFM库存中大约3000种香料成分的皮肤第95百分位数暴露与它们各自的TTC或DST进行比较。此外,随机选择代表性香料成分，并按产品类型分析暴露分布(即，化妆品/个人护理，家庭护理,口腔护理,和空气护理)和暴露途径。当与第95百分位的全身暴露相比时，发现76％的香料成分低于其各自的TTC限值。而99%低于吸入TTC限值。按产品类型划分的最低第95百分位的总暴露量来自家庭护理产品，然后是空气护理,和口腔护理产品。暴露量最高的是个人护理/化妆品。大多数香料成分（63％）的使用量<1公吨，估计环境对香料成分的暴露可能很低。
