PDF(Pubmed)
Abstract：
Breast cancer is one of the most common cancers in the world and leading cause of cancer-related death among women. Several studies indicated that Arg188His (rs3218536) polymorphism of X-ray repair cross-complementing 2 (XRCC2) may be associated with breast cancer risk. However, this association remains ambiguous. Thus, we performed a meta-analysis to provide more precise conclusion on this issue. A comprehensive search in PubMed, Google Scholar and ISI Web of Science was performed to select all relevant studies. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were applied to assess the strength of the relationships. A total of 17 studies with 5694 breast cancer cases and 6450 healthy subjects were identified. The pooled data revealed that XRCC2 Arg188His polymorphism was marginally with susceptibility to breast cancer globally under the heterozygote contrast (OR = 0.929, 95% CI = 0.873-0.987, p=0.018). Moreover, subgroup analysis by ethnicity revealed that this polymorphism was associated with breast cancer risk among Caucasians. On the whole, the present study demonstrates that the XRCC2 Arg188His polymorphism may contribute to an increased risk of breast cancer.
摘要：
乳腺癌是世界上最常见的癌症之一，也是女性癌症相关死亡的主要原因。多项研究表明，X射线修复交叉互补2（XRCC2）的Arg188His（rs3218536）多态性可能与乳腺癌风险有关。然而,这种联系仍然模棱两可。因此，我们进行了荟萃分析,以提供有关该问题的更准确结论.在PubMed中进行全面搜索,GoogleScholar和ISIWebofScience进行了选择所有相关研究。使用具有相应的95％置信区间（CI）的赔率比（OR）来评估关系的强度。总共确定了17项研究，涉及5694例乳腺癌病例和6450例健康受试者。汇总数据显示，在杂合子对比下，XRCC2Arg188His多态性与全球乳腺癌易感性略有差异（OR=0.929，95％CI=0.873-0.987，p=0.018）。此外，按种族划分的亚组分析显示,这种多态性与白种人患乳腺癌的风险相关.总的来说,本研究表明,XRCC2Arg188His多态性可能导致乳腺癌风险增加.
