PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiometabolic index (CMI) has been suggested as innovative measures for assessing the cardiometabolic status. However, there is a lack of relevant studies on exploring the relationship between CMI and insulin resistance (IR). Consequently, this study aims to examine the relationship between CMI and IR in subjects with type 2 diabetes mellitus (T2DM).
UNASSIGNED: A cross-sectional study was performed on 2493 patients with T2DM (including 1505 males and 988 females). IR was measured through the homeostatic model assessment of insulin resistance (HOMA-IR), which was defined as HOMI-IR≥2.69. The relationship between CMI and IR was evaluated with Spearman\'s correlation, ROC analysis, multiple logistic regression, generalized smooth curve fitting and subgroup analysis.
UNASSIGNED: CMI was correlated with HOMA-IR in patients with T2DM (Spearman correlation coefficient = 0.391 in females and 0.346 in males, P<0.001). Through the multiple logistic regression analysis, CMI was significantly correlated with IR (OR=1.30, 95% CI=1.15-1.47 in males and OR=1.62, 95% CI=1.32-1.99 in females). In addition, a non-linear correlation between CMI and IR risk was identified. The AUC of CMI (AUC = 0.702 for males and 0.733 for females, all p < 0.01) was the largest compared with traditional indexes of adiposity and blood lipids. According to the subgroup analysis, the two had a more significantly positive correlation in females, the elderly and subjects with HbA1c < 7%.
UNASSIGNED: In patients with T2DM, elevated CMI is significantly correlated with IR, as a useful index of IR.
UNASSIGNED: A cross-sectional study was performed on 2493 patients with T2DM (including 1505 males and 988 females). IR was measured through the homeostatic model assessment of insulin resistance (HOMA-IR), which was defined as HOMI-IR≥2.69. The relationship between CMI and IR was evaluated with Spearman\'s correlation, ROC analysis, multiple logistic regression, generalized smooth curve fitting and subgroup analysis.
UNASSIGNED: CMI was correlated with HOMA-IR in patients with T2DM (Spearman correlation coefficient = 0.391 in females and 0.346 in males, P<0.001). Through the multiple logistic regression analysis, CMI was significantly correlated with IR (OR=1.30, 95% CI=1.15-1.47 in males and OR=1.62, 95% CI=1.32-1.99 in females). In addition, a non-linear correlation between CMI and IR risk was identified. The AUC of CMI (AUC = 0.702 for males and 0.733 for females, all p < 0.01) was the largest compared with traditional indexes of adiposity and blood lipids. According to the subgroup analysis, the two had a more significantly positive correlation in females, the elderly and subjects with HbA1c < 7%.
UNASSIGNED: In patients with T2DM, elevated CMI is significantly correlated with IR, as a useful index of IR.
摘要：
■心脏代谢指数（CMI）已被建议作为评估心脏代谢状态的创新指标。然而,缺乏探讨CMI与胰岛素抵抗(IR)关系的相关研究。因此,本研究旨在探讨2型糖尿病（T2DM）患者的CMI与IR之间的关系。
■对2493名T2DM患者（包括1505名男性和988名女性）进行了横断面研究。IR通过胰岛素抵抗的稳态模型评估(HOMA-IR)来测量，定义为HOMI-IR≥2.69。CMI和IR之间的关系用Spearman相关评价，ROC分析,多元逻辑回归，广义光滑曲线拟合和子群分析。
■CMI与T2DM患者的HOMA-IR相关（Spearman相关系数=女性0.391，男性0.346，P<0.001)。通过多元Logistic回归分析,CMI与IR显著相关(男性OR=1.30,95%CI=1.15~1.47,女性OR=1.62,95%CI=1.32~1.99)。此外,确定了CMI和IR风险之间的非线性相关性.CMI的AUC（男性AUC=0.702，女性AUC=0.733，所有p<0.01）与传统的肥胖和血脂指标相比最大。根据亚组分析,两者在女性中具有更显著的正相关,老年人和HbA1c<7%的受试者。
■在T2DM患者中，CMI升高与IR显著相关，作为IR的有用指标。
■对2493名T2DM患者（包括1505名男性和988名女性）进行了横断面研究。IR通过胰岛素抵抗的稳态模型评估(HOMA-IR)来测量，定义为HOMI-IR≥2.69。CMI和IR之间的关系用Spearman相关评价，ROC分析,多元逻辑回归，广义光滑曲线拟合和子群分析。
■CMI与T2DM患者的HOMA-IR相关（Spearman相关系数=女性0.391，男性0.346，P<0.001)。通过多元Logistic回归分析,CMI与IR显著相关(男性OR=1.30,95%CI=1.15~1.47,女性OR=1.62,95%CI=1.32~1.99)。此外,确定了CMI和IR风险之间的非线性相关性.CMI的AUC（男性AUC=0.702，女性AUC=0.733，所有p<0.01）与传统的肥胖和血脂指标相比最大。根据亚组分析,两者在女性中具有更显著的正相关,老年人和HbA1c<7%的受试者。
■在T2DM患者中，CMI升高与IR显著相关，作为IR的有用指标。
