PDF(Pubmed)
Abstract：
Japan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal morphological abnormalities, whereas the cause of death in cases with non-morphological abnormalities can be detected through additional examinations. Molecular autopsy and postmortem genetic analyses are important additional examinations. They are capable of detecting inherited arrhythmias or inherited metabolic diseases, which are representative non-morphological disorders that cause sudden death, especially in infants and young people. In this review, we introduce molecular autopsy reports from Japan and describe our experience with representative cases. The relationships between drug-related deaths and genetic variants are also reviewed. Based on the presented information, molecular autopsy is expected to be used as routine examinations in death investigations because they can provide information to save new lives.
摘要：
日本有各种死亡调查系统；然而，外部检查,死后计算机断层扫描,宏观检查，无论使用何种系统，都要进行显微镜检查。这些检查可以揭示形态异常，而非形态学异常的死亡原因可以通过额外的检查来检测。分子尸检和死后遗传分析是重要的额外检查。它们能够检测遗传性心律失常或遗传性代谢疾病，它们是导致猝死的代表性非形态学疾病，尤其是婴儿和年轻人。在这次审查中,我们介绍了来自日本的分子尸检报告，并描述了我们对代表性病例的经验。还回顾了药物相关死亡与遗传变异之间的关系。根据提供的信息，分子尸检有望被用作死亡调查的常规检查，因为它们可以提供拯救新生命的信息。
