PDF(Pubmed)
Abstract：
The first stages of human life, which include the fetal period, infancy, and early childhood, are the most critical for human growth and development. This is the most vulnerable phase to health challenges due to the immature immune system and rapid development. Mycotoxins such as aflatoxins, ochratoxin A, patulin, fumonisins, zearalenone, and deoxynivalenol are secondary metabolites secreted by various fungal species, primarily Aspergillus, Fusarium, Penicillium, and Alternaria. Aflatoxins are one of the major mycotoxins produced in cereals and cereal-based foods by several species of Aspergillus, mainly Aspergillus flavus. In this context, this review provides a brief overview of the occurrence, exposure, legal regulations, and health effects of aflatoxins (B1, B2, G1, G2, and M1) in cereal-based baby foods and breast milk.
Human aflatoxin exposure in utero and through breast milk, infant formulas, cereals, and cereal-based foods has been linked to various health consequences, including adverse birth outcomes, impaired growth and development, immune system suppression, and hepatic dysfunction. Recent evidence suggests that especially infants and children are more susceptible to aflatoxins due to their lower body weight, lowered capacity to detoxify harmful substances, more restrictive diet, immature metabolism and elimination, and faster rates of growth and development. It is essential for both food safety and infant and child health that aflatoxins in cereal and cereal-based products are precisely detected, detoxified, and managed.
Human aflatoxin exposure in utero and through breast milk, infant formulas, cereals, and cereal-based foods has been linked to various health consequences, including adverse birth outcomes, impaired growth and development, immune system suppression, and hepatic dysfunction. Recent evidence suggests that especially infants and children are more susceptible to aflatoxins due to their lower body weight, lowered capacity to detoxify harmful substances, more restrictive diet, immature metabolism and elimination, and faster rates of growth and development. It is essential for both food safety and infant and child health that aflatoxins in cereal and cereal-based products are precisely detected, detoxified, and managed.
摘要：
目标：人类生命的第一阶段，其中包括胎儿期，婴儿期,和早期的童年，对人类的成长和发展至关重要。由于不成熟的免疫系统和快速发展，这是最容易受到健康挑战的阶段。霉菌毒素如黄曲霉毒素，曲霉毒素A,棒曲霉素,伏马菌素,玉米赤霉烯酮,脱氧雪腐镰刀菌烯醇是由各种真菌物种分泌的次级代谢产物，主要是曲霉,镰刀菌,青霉,还有Alternaria.黄曲霉毒素是几种曲霉在谷物和谷物食品中产生的主要霉菌毒素之一，主要是黄曲霉。在这种情况下，这篇综述简要概述了这种情况的发生，暴露,法律法规,以及谷类婴儿食品和母乳中黄曲霉毒素（B1，B2，G1，G2和M1）的健康影响。
结果：子宫内和母乳中的人类黄曲霉毒素暴露，婴儿配方奶粉,谷物,谷物食品与各种健康后果有关，包括不良出生结局，生长发育受损，免疫系统抑制，和肝功能障碍。最近的证据表明，特别是婴儿和儿童由于体重较低而更容易受到黄曲霉毒素的影响，降低了对有害物质的解毒能力，更严格的饮食，不成熟的新陈代谢和消除，以及更快的增长和发展速度。准确检测谷物和谷物产品中的黄曲霉毒素对于食品安全以及婴儿和儿童健康至关重要，解毒,并管理。
结果：子宫内和母乳中的人类黄曲霉毒素暴露，婴儿配方奶粉,谷物,谷物食品与各种健康后果有关，包括不良出生结局，生长发育受损，免疫系统抑制，和肝功能障碍。最近的证据表明，特别是婴儿和儿童由于体重较低而更容易受到黄曲霉毒素的影响，降低了对有害物质的解毒能力，更严格的饮食，不成熟的新陈代谢和消除，以及更快的增长和发展速度。准确检测谷物和谷物产品中的黄曲霉毒素对于食品安全以及婴儿和儿童健康至关重要，解毒,并管理。
