PDF(Pubmed)
Abstract：
OBJECTIVE: To assess the value of intraovarian PRP in women with low ovarian reserve.
METHODS: Screening of databases from inception to January 2023 using the keywords related to \"Platelet-rich plasma\" AND \"poor ovarian reserve\" OR \"ovarian failure\".
METHODS: Fourteen studies (1632 participants) were included, 10 included women with POR, 1 included women with POI and 3 included both POR and POI women.
METHODS: Extracted data included study settings, design, sample size, population characteristics, volume, timing and preparation of PRP administration, and outcome parameters.
RESULTS: AMH level was evaluated in 11 studies (2099 women). The mean difference (MD) was 0.09 with 95% CI of - 0.06, 0.24 (P = 0.25). Antral follicular count level was assessed in 6 studies (1399 women). The MD was 1.73 with 95% CI of 0.81, 2.66 (P < 0.001). The number of oocytes retrieved was evaluated in 7 studies (1413 women). The MD was 1.21 with 95% CI of 0.48, 1.94 (P = 0.001).
CONCLUSIONS: This systematic review found a significant improvement of AFC, the number of retrieved oocytes, the number of cleavage embryos and the cancellation rate in women with POR.
BACKGROUND: Registration number CRD42022365682.
METHODS: Screening of databases from inception to January 2023 using the keywords related to \"Platelet-rich plasma\" AND \"poor ovarian reserve\" OR \"ovarian failure\".
METHODS: Fourteen studies (1632 participants) were included, 10 included women with POR, 1 included women with POI and 3 included both POR and POI women.
METHODS: Extracted data included study settings, design, sample size, population characteristics, volume, timing and preparation of PRP administration, and outcome parameters.
RESULTS: AMH level was evaluated in 11 studies (2099 women). The mean difference (MD) was 0.09 with 95% CI of - 0.06, 0.24 (P = 0.25). Antral follicular count level was assessed in 6 studies (1399 women). The MD was 1.73 with 95% CI of 0.81, 2.66 (P < 0.001). The number of oocytes retrieved was evaluated in 7 studies (1413 women). The MD was 1.21 with 95% CI of 0.48, 1.94 (P = 0.001).
CONCLUSIONS: This systematic review found a significant improvement of AFC, the number of retrieved oocytes, the number of cleavage embryos and the cancellation rate in women with POR.
BACKGROUND: Registration number CRD42022365682.
摘要：
目的：评估卵巢内PRP在低卵巢储备妇女中的价值。
方法：使用与“富含血小板的血浆”和“卵巢储备不足”或“卵巢功能衰竭”相关的关键词对数据库进行筛选。
方法：纳入14项研究（1632名参与者），包括10名患有POR的女性，1名包括POI女性，3名包括POR和POI女性。
方法：提取的数据包括研究设置，设计,样本量,人口特征，volume,PRP管理的时机和准备，和结果参数。
结果：在11项研究（2099名女性）中评估了AMH水平。平均差异（MD）为0.09，95％CI为-0.06，0.24（P=0.25）。在6项研究（1399名女性）中评估了窦卵泡计数水平。MD为1.73，95%CI为0.81、2.66（P<0.001）。在7项研究（1413名女性）中评估了所获得的卵母细胞数量。MD为1.21，95%CI为0.48、1.94（P=0.001）。
结论：本系统综述发现AFC有显著改善，回收的卵母细胞数量，POR女性的卵裂胚胎数量和取消率。
背景：注册号CRD42022365682。
方法：使用与“富含血小板的血浆”和“卵巢储备不足”或“卵巢功能衰竭”相关的关键词对数据库进行筛选。
方法：纳入14项研究（1632名参与者），包括10名患有POR的女性，1名包括POI女性，3名包括POR和POI女性。
方法：提取的数据包括研究设置，设计,样本量,人口特征，volume,PRP管理的时机和准备，和结果参数。
结果：在11项研究（2099名女性）中评估了AMH水平。平均差异（MD）为0.09，95％CI为-0.06，0.24（P=0.25）。在6项研究（1399名女性）中评估了窦卵泡计数水平。MD为1.73，95%CI为0.81、2.66（P<0.001）。在7项研究（1413名女性）中评估了所获得的卵母细胞数量。MD为1.21，95%CI为0.48、1.94（P=0.001）。
结论：本系统综述发现AFC有显著改善，回收的卵母细胞数量，POR女性的卵裂胚胎数量和取消率。
背景：注册号CRD42022365682。
