{Reference Type}: Meta-Analysis
{Title}: The value of intraovarian autologous platelet rich plasma in women with poor ovarian reserve or ovarian insufficiency: a systematic review and meta-analysis.
{Author}: Maged AM;Mohsen RA;Salah N;Ragab WS;
{Journal}: BMC Pregnancy Childbirth
{Volume}: 24
{Issue}: 1
{Year}: 2024 Jan 27
{Factor}: 3.105
{DOI}: 10.1186/s12884-024-06251-2
{Abstract}: <B>OBJECTIVE: </B>To assess the value of intraovarian PRP in women with low ovarian reserve.<BR><B>METHODS: </B>Screening of databases from inception to January 2023 using the keywords related to "Platelet-rich plasma" AND "poor ovarian reserve" OR "ovarian failure".<BR><B>METHODS: </B>Fourteen studies (1632 participants) were included, 10 included women with POR, 1 included women with POI and 3 included both POR and POI women.<BR><B>METHODS: </B>Extracted data included study settings, design, sample size, population characteristics, volume, timing and preparation of PRP administration, and outcome parameters.<BR><B>RESULTS: </B>AMH level was evaluated in 11 studies (2099 women). The mean difference (MD) was 0.09 with 95% CI of - 0.06, 0.24 (P = 0.25). Antral follicular count level was assessed in 6 studies (1399 women). The MD was 1.73 with 95% CI of 0.81, 2.66 (P < 0.001). The number of oocytes retrieved was evaluated in 7 studies (1413 women). The MD was 1.21 with 95% CI of 0.48, 1.94 (P = 0.001).<BR><B>CONCLUSIONS: </B>This systematic review found a significant improvement of AFC, the number of retrieved oocytes, the number of cleavage embryos and the cancellation rate in women with POR.<BR><B>BACKGROUND: </B>Registration number CRD42022365682.