Abstract：
The connection between maternal microbiota and infant health has been greatly garnered interest for therapeutic purposes. The early resident microbiota perpetually exhibits much more flexibility as compared to that of the adults, and therefore, constant need of understanding the infant as well as maternal microbiota and their implications however has increased. In this review, we focus mainly on the diversity of overall maternal microbiota including the gut, vaginal, colostrum microbiota and how inflammatory markers fluctuate throughout the normal pregnancy as well in pregnancy with complications. The maternal body undergoes a cascade of physiological changes including hormonal, immunological and metabolic events to support the fetal development. These changes at the time of pregnancy have been correlated with alteration in the composition and diversity of maternal microbiota. Along with alteration in microbiome, the levels of circulatory cytokines fluctuate by complex network of inflammation, in order to prevent the fetal allograft throughout the pregnancy. The dynamic relationship of gut microbiota with the host and its immune system allows one to have greater insights of their role in pregnancy and newborn\'s health. Emerging evidence suggests that the vertical transmission of bacterial community from mother to newborn may begin in-utero which contributes in developing the immune system and infant gut microbiota.
摘要：
母体微生物群与婴儿健康之间的联系已极大地引起了用于治疗目的的兴趣。与成年人相比，早期的常驻微生物群永久表现出更大的灵活性，因此,然而，人们不断需要了解婴儿和母体的微生物群及其影响。在这次审查中,我们主要关注包括肠道在内的整个母体微生物群的多样性，阴道,初乳微生物群以及炎症标志物在整个正常妊娠以及妊娠并发症中如何波动。母体经历一系列生理变化，包括荷尔蒙，免疫和代谢事件，以支持胎儿发育。怀孕时的这些变化与母体微生物群的组成和多样性的改变有关。随着微生物组的改变，循环细胞因子的水平因复杂的炎症网络而波动，为了防止胎儿在整个孕期移植。肠道微生物群与宿主及其免疫系统的动态关系使人们能够更好地了解它们在妊娠和新生儿健康中的作用。新出现的证据表明，细菌群落从母亲到新生儿的垂直传播可能在子宫内开始，这有助于发育免疫系统和婴儿肠道微生物群。
