PDF(Pubmed)
Abstract：
Toxoplasma (T.) gondii is an obligate intracellular parasite with felids, including domestic cats, as definitive hosts. In immunocompetent individuals, T. gondii infection is usually asymptomatic. However, under immunosuppression, it may have severe pathological impacts, which often result from the reactivation of a chronic infection. In this case study, a 21-month-old female domestic shorthair cat-diagnosed with primary immune-mediated hemolytic anemia three months prior and treated with cyclosporine and prednisolone-presented with acute tachypnea, dyspnea, diarrhea, and anorexia. Thoracic radiography suggested severe pneumonia. Testing for Mycoplasma spp., Anaplasma spp., Ehrlichia spp., and lungworm infection was negative. Serology for T. gondii revealed seroconversion of IgG, but not of IgM, indicating previous exposure to T. gondii. The cat remained stable but tachypneic for three days, followed by an acute onset of dyspnea and clinical deterioration, after which euthanasia was elected. Numerous protozoa were present in a postmortem transtracheal bronchoalveolar lavage and fine-needle aspiration of the lung. Microsatellite typing classified the extracted DNA as T. gondii type II variant TgM-A. This case demonstrates that T. gondii reactivation, leading to fulminant pneumonia, can be a sequela of immunosuppressive treatment in cats and should, therefore, be considered as a differential diagnosis in immunosuppressed cats with acute-onset respiratory signs. Rapid diagnosis may prevent fatal consequences.
摘要：
弓形虫(T.)弓形虫是一种专性的细胞内寄生虫，包括家猫,作为确定的主持人。在有免疫能力的个体中，弓形虫感染通常无症状。然而,在免疫抑制下，它可能会产生严重的病理影响，这通常是由慢性感染的重新激活引起的。在这个案例研究中,一只21个月大的家养雌性短毛猫，三个月前被诊断患有原发性免疫介导的溶血性贫血，并接受环孢素和泼尼松龙治疗，表现为急性呼吸急促，呼吸困难,腹泻,和厌食症。胸部X线检查提示重症肺炎。支原体属的测试。,支原体属。,埃里希菌属。,肺虫感染呈阴性。弓形虫的血清学显示IgG的血清转化，但不是IgM,表明以前接触过弓形虫。这只猫保持稳定，但有三天的感觉，随后是呼吸困难的急性发作和临床恶化，之后，安乐死当选。死后气管支气管肺泡灌洗和肺部细针抽吸中存在许多原生动物。微卫星分型将提取的DNA分类为弓形虫II型变异体TgM-A。这个案例表明弓形虫重新激活，导致暴发性肺炎,可能是猫免疫抑制治疗的后遗症，因此,被认为是具有急性发作呼吸体征的免疫抑制猫的鉴别诊断。快速诊断可以防止致命后果。
