Abstract：
BACKGROUND: Pseudotumor cerebri (PC) in prepubertal patients displays certain characteristics that differentiate it from its presentation at the postpubertal stage. The aim of this study is to describe the characteristics of paediatric patients diagnosed with PC at our centre and to compare them according to their pubertal status.
METHODS: We included patients aged between 1 and 18 years who were diagnosed with PC in a tertiary-level hospital between 2006 and 2019 and who met the updated diagnostic criteria for PC. They were classified according to body weight and pubertal status. Subsequently, we analysed results from lumbar punctures, neuroimaging studies, ophthalmological assessments, and treatments received during follow-up.
RESULTS: We included 28 patients, of whom 22 were of prepubertal age and 6 were of postpubertal age. The mean age (standard deviation) was 9.04 (2.86) years. Among the postpubertal patients, 83.3% were boys, 66.7% of whom presented overweight/obesity. In the group of prepubertal patients, 27% were boys, 31.8% of whom were overweight. The most frequent symptoms were headache (89.9%) and blurred vision (42.9%). All patients presented papilloedema, and 21.4% manifested sixth nerve palsy. Possible triggers were identified in 28.6% of cases. Nineteen percent of patients presented clinical recurrence, all of whom were prepubertal patients. Complete clinical resolution was achieved in 55.6% of patients.
CONCLUSIONS: Prepubertal patients with PC show lower prevalence of obesity, higher prevalence of secondary aetiologies, and higher recurrence rates than postpubertal patients.
METHODS: We included patients aged between 1 and 18 years who were diagnosed with PC in a tertiary-level hospital between 2006 and 2019 and who met the updated diagnostic criteria for PC. They were classified according to body weight and pubertal status. Subsequently, we analysed results from lumbar punctures, neuroimaging studies, ophthalmological assessments, and treatments received during follow-up.
RESULTS: We included 28 patients, of whom 22 were of prepubertal age and 6 were of postpubertal age. The mean age (standard deviation) was 9.04 (2.86) years. Among the postpubertal patients, 83.3% were boys, 66.7% of whom presented overweight/obesity. In the group of prepubertal patients, 27% were boys, 31.8% of whom were overweight. The most frequent symptoms were headache (89.9%) and blurred vision (42.9%). All patients presented papilloedema, and 21.4% manifested sixth nerve palsy. Possible triggers were identified in 28.6% of cases. Nineteen percent of patients presented clinical recurrence, all of whom were prepubertal patients. Complete clinical resolution was achieved in 55.6% of patients.
CONCLUSIONS: Prepubertal patients with PC show lower prevalence of obesity, higher prevalence of secondary aetiologies, and higher recurrence rates than postpubertal patients.
摘要：
背景：青春期前患者的假性脑瘤（PC）表现出某些特征，可以将其与青春期后阶段的表现区分开来。这项研究的目的是描述在我们中心诊断为PC的儿科患者的特征，并根据他们的青春期状态进行比较。
方法：我们纳入了年龄在1至18岁之间的患者，这些患者在2006年至2019年间在三级医院被诊断为PC，并且符合更新的PC诊断标准。根据体重和青春期状态对它们进行分类。随后，我们分析了腰椎穿刺的结果，神经影像学研究，眼科评估，和随访期间接受的治疗。
结果：我们纳入了28例患者，其中22人处于青春期前年龄，6人处于青春期后年龄。平均年龄（标准差）为9.04（2.86）岁。在青春期后患者中，83.3%是男孩，66.7%的人表现出超重/肥胖。在青春期前患者组中，27%是男孩，31.8％的人超重。最常见的症状是头痛（89.9％）和视力模糊（42.9％）。所有患者均出现乳头水肿，21.4%表现为第六神经麻痹。在28.6%的病例中发现了可能的触发因素。19%的患者出现临床复发,所有患者均为青春期前患者。55.6%的患者获得了完整的临床疗效。
结论：青春期前PC患者的肥胖患病率较低，继发性病因患病率较高，复发率高于青春期后患者。
方法：我们纳入了年龄在1至18岁之间的患者，这些患者在2006年至2019年间在三级医院被诊断为PC，并且符合更新的PC诊断标准。根据体重和青春期状态对它们进行分类。随后，我们分析了腰椎穿刺的结果，神经影像学研究，眼科评估，和随访期间接受的治疗。
结果：我们纳入了28例患者，其中22人处于青春期前年龄，6人处于青春期后年龄。平均年龄（标准差）为9.04（2.86）岁。在青春期后患者中，83.3%是男孩，66.7%的人表现出超重/肥胖。在青春期前患者组中，27%是男孩，31.8％的人超重。最常见的症状是头痛（89.9％）和视力模糊（42.9％）。所有患者均出现乳头水肿，21.4%表现为第六神经麻痹。在28.6%的病例中发现了可能的触发因素。19%的患者出现临床复发,所有患者均为青春期前患者。55.6%的患者获得了完整的临床疗效。
结论：青春期前PC患者的肥胖患病率较低，继发性病因患病率较高，复发率高于青春期后患者。
