PDF(Pubmed)
Abstract：
Nausea is an uncomfortable sensation that accompanies many therapeutics, especially diabetes treatments involving glucagon-like peptide-1 receptor (GLP1R) agonists. Recent studies in mice have revealed that GLP1R-expressing neurons in the area postrema play critical roles in nausea. Here, we characterized a ligand-conjugated saporin that can efficiently ablate GLP1R+ cells from humans, mice, and the Suncus murinus, a small animal model capable of emesis. This new tool provides a strategy to manipulate specific neural pathways in the area postrema in the Suncus murinus and may help elucidate roles of area postrema GLP1R+ neurons in emesis during therapeutics involving GLP1R agonists.
摘要：
恶心是一种不舒服的感觉，伴随着许多治疗方法，尤其是涉及胰高血糖素样肽-1受体（GLP1R）激动剂的糖尿病治疗。最近在小鼠中的研究表明，在后区域中表达GLP1R的神经元在恶心中起关键作用。这里,我们表征了一种配体缀合的皂草素，可以有效地从人类中消融GLP1R+细胞，老鼠,和Suncusmurinus,一种能呕吐的小动物模型。这种新工具提供了一种策略来操纵Suncusmurinus的后区域中的特定神经通路，并且可能有助于阐明在涉及GLP1R激动剂的治疗过程中，后区域GLP1R神经元在呕吐中的作用。
