%0 Journal Article
%T Characterizing a new tool to manipulate area postrema GLP1R+ neurons across species.
%A Fulton S
%A Horn CC
%A Zhang C
%J Physiol Behav
%V 276
%N 0
%D 2024 Mar 15
%M 38272107
%F 3.742
%R 10.1016/j.physbeh.2024.114474
%X Nausea is an uncomfortable sensation that accompanies many therapeutics, especially diabetes treatments involving glucagon-like peptide-1 receptor (GLP1R) agonists. Recent studies in mice have revealed that GLP1R-expressing neurons in the area postrema play critical roles in nausea. Here, we characterized a ligand-conjugated saporin that can efficiently ablate GLP1R+ cells from humans, mice, and the Suncus murinus, a small animal model capable of emesis. This new tool provides a strategy to manipulate specific neural pathways in the area postrema in the Suncus murinus and may help elucidate roles of area postrema GLP1R+ neurons in emesis during therapeutics involving GLP1R agonists.