Abstract：
OBJECTIVE: To examine the association of serum connecting peptide (C-peptide) concentrations with gestational diabetes mellitus (GDM) risk among Chinese women.
METHODS: A nested case-control study was conducted on 436 reproductive-aged women, involving 218 GDM cases and 218 controls matched at 1:1 by maternal age, in Beijing, China between January 2016 and December 2017. Fasting serum C-peptide were successively determined at 10-14 and 15-20 weeks of gestation. Restricted cubic spline and logistic regression analyses were utilized, and receiver operating characteristic (ROC) curves were generated to evaluate the predictive capacity of C-peptide for GDM.
RESULTS: Fasting serum C-peptide concentrations exhibited a significant decrease from the initial to the subsequent trimester in females with normal glucose tolerance (NGT). For each 1 log ng/mL increase of fasting serum C-peptide during the first and second trimesters, GDM risk increased by 2.38-fold [odds ratio (OR): 2.38, 95% confidence intervals (95%CI): 1.33-4.40] and 3.07-fold (OR: 3.07, 95%CI: 1.49-6.62), respectively. The areas under the ROC curves for the first- and second-trimester C-peptide were 80.4% and 82.4%.
CONCLUSIONS: Our findings revealed a positive correlation between fasting serum C-peptide during the first and second trimesters and the risk of GDM or its subtypes, underscoring the potential of C-peptide as a predictor for GDM development.
METHODS: A nested case-control study was conducted on 436 reproductive-aged women, involving 218 GDM cases and 218 controls matched at 1:1 by maternal age, in Beijing, China between January 2016 and December 2017. Fasting serum C-peptide were successively determined at 10-14 and 15-20 weeks of gestation. Restricted cubic spline and logistic regression analyses were utilized, and receiver operating characteristic (ROC) curves were generated to evaluate the predictive capacity of C-peptide for GDM.
RESULTS: Fasting serum C-peptide concentrations exhibited a significant decrease from the initial to the subsequent trimester in females with normal glucose tolerance (NGT). For each 1 log ng/mL increase of fasting serum C-peptide during the first and second trimesters, GDM risk increased by 2.38-fold [odds ratio (OR): 2.38, 95% confidence intervals (95%CI): 1.33-4.40] and 3.07-fold (OR: 3.07, 95%CI: 1.49-6.62), respectively. The areas under the ROC curves for the first- and second-trimester C-peptide were 80.4% and 82.4%.
CONCLUSIONS: Our findings revealed a positive correlation between fasting serum C-peptide during the first and second trimesters and the risk of GDM or its subtypes, underscoring the potential of C-peptide as a predictor for GDM development.
摘要：
目的：探讨中国女性血清连接肽（C肽）浓度与妊娠期糖尿病（GDM）风险的关系。
方法：对436名育龄妇女进行巢式病例对照研究，涉及218例GDM病例和218例对照，按产妇年龄1：1匹配，在北京,2016年1月至2017年12月的中国。在妊娠10-14和15-20周连续测定空腹血清C肽。利用了限制性三次样条和逻辑回归分析，和受试者工作特征（ROC）曲线，以评估C肽对GDM的预测能力。
结果：在糖耐量正常（NGT）的女性中，从最初到随后的三个月，空腹血清C肽浓度显着降低。对于第一和第二三个月期间空腹血清C肽的每1logng/ml增加，GDM风险增加2.38倍[优势比（OR）：2.38，95％置信区间（95CI）：1.33-4.40]和3.07倍（OR：3.07，95CI：1.49-6.62），分别。妊娠早期和中期C肽的ROC曲线下面积分别为80.4%和82.4%。
结论：我们的发现揭示了妊娠早期和中期的空腹血清C肽与GDM或其亚型的风险之间呈正相关。强调C肽作为GDM发展预测因子的潜力。
方法：对436名育龄妇女进行巢式病例对照研究，涉及218例GDM病例和218例对照，按产妇年龄1：1匹配，在北京,2016年1月至2017年12月的中国。在妊娠10-14和15-20周连续测定空腹血清C肽。利用了限制性三次样条和逻辑回归分析，和受试者工作特征（ROC）曲线，以评估C肽对GDM的预测能力。
结果：在糖耐量正常（NGT）的女性中，从最初到随后的三个月，空腹血清C肽浓度显着降低。对于第一和第二三个月期间空腹血清C肽的每1logng/ml增加，GDM风险增加2.38倍[优势比（OR）：2.38，95％置信区间（95CI）：1.33-4.40]和3.07倍（OR：3.07，95CI：1.49-6.62），分别。妊娠早期和中期C肽的ROC曲线下面积分别为80.4%和82.4%。
结论：我们的发现揭示了妊娠早期和中期的空腹血清C肽与GDM或其亚型的风险之间呈正相关。强调C肽作为GDM发展预测因子的潜力。
