{Reference Type}: Journal Article
{Title}: Maternal fasting serum C-peptide concentrations in the first and second trimesters and subsequent risk of gestational diabetes mellitus: A nested case-control study among Chinese women.
{Author}: Zhao C;Liu H;Deng Y;Wu H;Wang S;Lyu X;Lei J;Yang H;Hu M;Zhao Y;Ma X;Zou X;Yang Y;
{Journal}: Diabetes Res Clin Pract
{Volume}: 208
{Issue}: 0
{Year}: 2024 Feb 23
{Factor}: 8.18
{DOI}: 10.1016/j.diabres.2024.111111
{Abstract}: <B>OBJECTIVE: </B>To examine the association of serum connecting peptide (C-peptide) concentrations with gestational diabetes mellitus (GDM) risk among Chinese women.<BR><B>METHODS: </B>A nested case-control study was conducted on 436 reproductive-aged women, involving 218 GDM cases and 218 controls matched at 1:1 by maternal age, in Beijing, China between January 2016 and December 2017. Fasting serum C-peptide were successively determined at 10-14 and 15-20 weeks of gestation. Restricted cubic spline and logistic regression analyses were utilized, and receiver operating characteristic (ROC) curves were generated to evaluate the predictive capacity of C-peptide for GDM.<BR><B>RESULTS: </B>Fasting serum C-peptide concentrations exhibited a significant decrease from the initial to the subsequent trimester in females with normal glucose tolerance (NGT). For each 1 log ng/mL increase of fasting serum C-peptide during the first and second trimesters, GDM risk increased by 2.38-fold [odds ratio (OR): 2.38, 95% confidence intervals (95%CI): 1.33-4.40] and 3.07-fold (OR: 3.07, 95%CI: 1.49-6.62), respectively. The areas under the ROC curves for the first- and second-trimester C-peptide were 80.4% and 82.4%.<BR><B>CONCLUSIONS: </B>Our findings revealed a positive correlation between fasting serum C-peptide during the first and second trimesters and the risk of GDM or its subtypes, underscoring the potential of C-peptide as a predictor for GDM development.