PDF(Pubmed)
Abstract：
BACKGROUND: Dysmenorrhea and premenstrual syndrome (PMS) are common periodic and frequent complications in women of reproductive age that can negatively affect health and quality of life. The present study examined the effects of curcumin on the severity of dysmenorrhea and PMS symptoms.
METHODS: A systematic review and meta-analysis of randomized controlled trials was conducted by searching databases such as the Cochrane Library, EMBASE, Scopus, PubMed, and Web of Science from inception to January 2023. Article screening was performed using Endnote ver. X8 (Clarivate). Review Manager (RevMan ver. 5.3; Cochrane) was used for the quality assessment and meta-analysis. A total of 147 studies were screened, of which five were finally selected for quantitative and qualitative analyses. The studies were conducted between 2015 and 2021, and a total of 379 participants with a mean age of 23.33±5.54 years had been recruited in these studies.
RESULTS: The meta-analysis showed that curcumin consumption could significantly reduce the severity of dysmenorrhea (mean difference, -1.25; 95% confidence interval [CI], -1.52 to -0.98; three studies; I2=31%) and the overall score of PMS (standardized mean difference, -1.41; 95% CI, -1.81 to -1.02; two studies; I2=0%).
CONCLUSIONS: The reduction in the severity of PMS and dysmenorrhea has been attributed to curcumin\'s anti-inflammatory and antidepressant activities. Although the findings suggest that curcumin may be an effective treatment for reducing the severity of PMS and dysmenorrhea, further research with a larger number of participants from various socioeconomic levels and a longer duration of treatment is needed to evaluate the effective dose of curcumin.
METHODS: A systematic review and meta-analysis of randomized controlled trials was conducted by searching databases such as the Cochrane Library, EMBASE, Scopus, PubMed, and Web of Science from inception to January 2023. Article screening was performed using Endnote ver. X8 (Clarivate). Review Manager (RevMan ver. 5.3; Cochrane) was used for the quality assessment and meta-analysis. A total of 147 studies were screened, of which five were finally selected for quantitative and qualitative analyses. The studies were conducted between 2015 and 2021, and a total of 379 participants with a mean age of 23.33±5.54 years had been recruited in these studies.
RESULTS: The meta-analysis showed that curcumin consumption could significantly reduce the severity of dysmenorrhea (mean difference, -1.25; 95% confidence interval [CI], -1.52 to -0.98; three studies; I2=31%) and the overall score of PMS (standardized mean difference, -1.41; 95% CI, -1.81 to -1.02; two studies; I2=0%).
CONCLUSIONS: The reduction in the severity of PMS and dysmenorrhea has been attributed to curcumin\'s anti-inflammatory and antidepressant activities. Although the findings suggest that curcumin may be an effective treatment for reducing the severity of PMS and dysmenorrhea, further research with a larger number of participants from various socioeconomic levels and a longer duration of treatment is needed to evaluate the effective dose of curcumin.
摘要：
痛经和经前期综合征（PMS）是育龄妇女常见的周期性和频繁的并发症，会对健康和生活质量产生负面影响。本研究检查了姜黄素对痛经和PMS症状的严重程度的影响。通过搜索CochraneLibrary等数据库，对随机对照试验进行了系统评价和荟萃分析。EMBASE,Scopus,PubMed,和WebofScience从成立到2023年1月。使用Endnotever进行文章筛选。X8（澄清）。审核经理(RevManver.5.3；Cochrane）用于质量评估和荟萃分析。共筛选了147项研究，其中最终选择了五个进行定量和定性分析。这些研究在2015年至2021年之间进行，总共招募了379名平均年龄为23.33±5.54岁的参与者。荟萃分析表明，食用姜黄素可以显着降低痛经的严重程度（平均差异，-1.25；95%置信区间[CI]，-1.52至-0.98；三项研究；I2=31%）和PMS总分（标准化平均差，-1.41；95%CI，-1.81至-1.02；两项研究；I2=0%）。PMS和痛经严重程度的降低归因于姜黄素的抗炎和抗抑郁活性。尽管研究结果表明，姜黄素可能是一种有效的治疗方法，可以减轻PMS和痛经的严重程度，需要对更多来自不同社会经济水平的参与者进行进一步研究,并且需要更长的治疗时间来评估姜黄素的有效剂量.
