Abstract：
While the effects of progesterone on body weight and appetite in pre-menopausal conditions have been well elucidated, its effects in post-menopausal conditions have not been clarified. On the contrary, the effects of estrogen on body weight and appetite in post-menopausal conditions have been well established. In this study, the effects of progesterone treatment on body weight, appetite, and fat mass in ovariectomized rats were evaluated. In addition, the central and/or peripheral levels of oxytocin (OT), leptin, and their receptors, which are potent anorectic factors, were examined. Female rats were ovariectomized and divided into control, progesterone-treated, and estrogen-treated groups. Body weight, food intake, and subcutaneous fat mass were lower in both the progesterone and estrogen groups than in the control group. The estrogen group exhibited higher serum OT levels than the control group, whereas the OT levels of the progesterone and control groups did not differ. The serum leptin levels of both the progesterone and estrogen groups were lower than those of the control group. Gene expression analysis of OT, leptin, and their receptors in the hypothalamus and adipose tissue found few significant differences among the groups. Hypothalamic neuropeptide Y (NPY) and pro-opiomelanocortin (POMC) mRNA levels involved in appetite regulation were slightly altered in the progesterone and estrogen groups. These findings suggest that progesterone treatment may have favorable effects on body weight, appetite, and fat mass regulation in post-menopausal conditions and that the mechanisms underlying these effects of progesterone differ from those underlying the effects of estrogen.
摘要：
虽然绝经前孕酮对体重和食欲的影响已经很好地阐明，其在绝经后疾病中的作用尚未明确.相反,雌激素对绝经后患者体重和食欲的影响已得到证实。在这项研究中,黄体酮治疗对体重的影响，食欲,评估去卵巢大鼠的脂肪量。此外,催产素（OT）的中枢和/或外周水平，瘦素,和它们的受体，这些是有效的厌食因素，进行了检查。雌性大鼠切除卵巢,分为对照组,黄体酮治疗，和雌激素治疗组。体重,食物摄入量,孕激素组和雌激素组的皮下脂肪量均低于对照组。雌激素组血清OT水平高于对照组，而孕酮组和对照组的OT水平没有差异。孕激素组和雌激素组的血清瘦素水平均低于对照组。OT基因表达分析,瘦素,它们在下丘脑和脂肪组织中的受体在各组之间发现了很少的显著差异。在黄体酮和雌激素组中，参与食欲调节的下丘脑神经肽Y（NPY）和前黑皮质素（POMC）mRNA水平略有改变。这些结果表明，黄体酮治疗可能对体重有有利的影响，食欲,和绝经后条件下的脂肪量调节，孕激素这些作用的潜在机制与雌激素的潜在机制不同。
