Abstract：
The effectiveness of polypropylene (PP) mesh is often compromised by severe inflammation. Engineering anti-inflammatory coatings has significant implications for PP mesh to repair unwanted hernias. Here, we presented a facile strategy to develop an anti-fouling coating consisting of zwitterionic poly(carboxybetaine methacrylate) (PCBMA), which could prohibit protein adsorption to endow PP mesh with anti-inflammatory efficacy. The incorporation of PCBMA coating had little impact on the raw features of PP mesh. While the modified mesh PCBMA-PP possessed noticeable hydrophilicity increase and surface charge reduction. The excellent lubricity and surface stability enabled PCBMA-PP to exhibit superior anti-fouling capacity, thus efficiently inhibiting the adsorption of proteins. In vivo experiments showed that incorporating the PCBMA layer could provide PP meshes with outstanding anti-inflammatory effects and tissue compatibility for repairing hernias.
摘要：
聚丙烯（PP）网眼的有效性经常受到严重炎症的影响。工程抗炎涂层对PP网片修复不需要的疝具有重要意义。这里,我们提出了一种简单的策略来开发由两性离子聚（羧基甜菜碱甲基丙烯酸酯）（PCBMA）组成的防污涂层，这可能会阻止蛋白质的吸附，从而赋予PP网状物抗炎功效。PCBMA涂层的掺入对PP网的原始特性影响不大。而改性的网状PCBMA-PP具有显著的亲水性增加和表面电荷减少。优异的润滑性和表面稳定性使PCBMA-PP具有优异的防污能力，从而有效抑制蛋白质的吸附。体内实验表明，掺入PCBMA层可以为修复疝提供具有出色抗炎作用和组织相容性的PP网。
