PDF(Pubmed)
Abstract：
BACKGROUND: Cerebellar alterations, including both volumetric changes in the cerebellar vermis and dysfunctions of the corticocerebellar connections, have been documented in psychotic disorders. Starting from the clinical observation of a bipolar patient with cerebellar hypoplasia, the purpose of this review is to summarize the data in the literature about the association between hypoplasia of the cerebellar vermis and psychotic disorders [schizophrenia (SCZ) and bipolar disorder (BD)].
METHODS: A bibliographic search on PubMed has been conducted, and 18 articles were finally included in the review: five used patients with BD, 12 patients with SCZ and one subject at psychotic risk.
RESULTS: For SCZ patients and subjects at psychotic risk, the results of most of the reviewed studies seem to suggest a gray matter volume reduction coupled with an increase in white matter volumes in the cerebellar vermis, compared to healthy controls. Instead, the results of the studies on BD patients are more heterogeneous with evidence showing a reduction, no difference or even an increase in cerebellar vermis volume compared to healthy controls.
CONCLUSIONS: From the results of the reviewed studies, a possible correlation emerged between cerebellar vermis hypoplasia and psychotic disorders, especially SCZ, ultimately supporting the hypothesis of psychotic disorders as neurodevelopmental disorders.
METHODS: A bibliographic search on PubMed has been conducted, and 18 articles were finally included in the review: five used patients with BD, 12 patients with SCZ and one subject at psychotic risk.
RESULTS: For SCZ patients and subjects at psychotic risk, the results of most of the reviewed studies seem to suggest a gray matter volume reduction coupled with an increase in white matter volumes in the cerebellar vermis, compared to healthy controls. Instead, the results of the studies on BD patients are more heterogeneous with evidence showing a reduction, no difference or even an increase in cerebellar vermis volume compared to healthy controls.
CONCLUSIONS: From the results of the reviewed studies, a possible correlation emerged between cerebellar vermis hypoplasia and psychotic disorders, especially SCZ, ultimately supporting the hypothesis of psychotic disorders as neurodevelopmental disorders.
摘要：
背景：小脑改变，包括小脑疣的体积变化和皮质小脑连接的功能障碍，已经被证明患有精神病。从1例小脑发育不全的双相病人的临床观察出发,这篇综述的目的是总结文献中有关小脑疣发育不全与精神病[精神分裂症（SCZ）和双相情感障碍（BD）]之间关联的数据。
方法：已在PubMed上进行了书目搜索，并最终纳入18篇文章：5例BD患者，12名SCZ患者和一名有精神病风险的受试者。
结果：对于SCZ患者和有精神病风险的受试者，大多数审查的研究结果似乎表明，灰质体积减少，再加上白质体积的增加，在小脑疣，与健康对照相比。相反，对BD患者的研究结果更为异质，证据显示减少，与健康对照组相比，小脑的椎骨体积没有差异甚至增加。
结论：从审查的研究结果来看，小脑蠕虫发育不全和精神病之间可能存在相关性，尤其是SCZ,最终支持精神病作为神经发育障碍的假设。
方法：已在PubMed上进行了书目搜索，并最终纳入18篇文章：5例BD患者，12名SCZ患者和一名有精神病风险的受试者。
结果：对于SCZ患者和有精神病风险的受试者，大多数审查的研究结果似乎表明，灰质体积减少，再加上白质体积的增加，在小脑疣，与健康对照相比。相反，对BD患者的研究结果更为异质，证据显示减少，与健康对照组相比，小脑的椎骨体积没有差异甚至增加。
结论：从审查的研究结果来看，小脑蠕虫发育不全和精神病之间可能存在相关性，尤其是SCZ,最终支持精神病作为神经发育障碍的假设。
