METHODS: Nineteen patients with UTLE, 12 with BTLE, and 15 healthy controls were enrolled. Resting state high-density electroencephalography (128 channels) was recorded for 15 min with closed eyes. We obtained a set of stable scalp maps representing the EEG activity, named microstates, from which we acquired the following variables: global explained variance (GEV), mean duration (MD), time coverage (TC), and frequency of occurrence (FO). Two-way repeated measures analysis of variance was used to compare groups, and Spearman correlation was performed to study the maps in association with the clinical and neuropsychological data.
RESULTS: Patients with BTLE and UTLE showed differences in most of the parameters (GEV, MD, TC, FO) of the four microstate maps (A-D) compared to controls. Patients with BTLE showed a significant increase in all parameters for the microstates in Map-A and a decrease in Map-D compared to UTLE and controls. We observed a correlation between Map-A, disease duration, and spatial short-term memory, whereas microstate Map-D was correlated with the global intelligence score and short-term memory performance.
CONCLUSIONS: A global alteration of the neural dynamics was observed in patients with TLE compared to controls. A different pattern of EEG microstate abnormalities was identified in BTLE compared to UTLE, which might represent a distinctive biomarker.
方法:19例UTLE患者,12与BTLE,纳入15名健康对照。闭眼记录静息状态高密度脑电图(128通道)15分钟。我们获得了一组代表脑电图活动的稳定头皮图,命名为微型国家,从中我们获得了以下变量:全局解释方差(GEV),平均持续时间(MD),时间覆盖范围(TC),和出现频率(FO)。双向重复测量方差分析用于比较组,和Spearman相关性被用来研究与临床和神经心理学数据相关的地图。
结果:BTLE和UTLE患者在大多数参数上显示出差异(GEV,MD,TC,与对照相比,四个微观状态图(A-D)的FO)。与UTLE和对照相比,具有BTLE的患者显示Map-A中的微状态的所有参数的显著增加和Map-D的降低。我们观察到Map-A之间的相关性,疾病持续时间,和空间短期记忆,而微态Map-D与整体智力评分和短期记忆表现相关。
结论:与对照组相比,在TLE患者中观察到神经动力学的整体改变。与UTLE相比,BTLE中发现了不同模式的EEG微状态异常,这可能代表了一种独特的生物标志物。