Abstract：
Quercetin, a naturally occurring polyphenolic compound found in abundance in vegetables and fruits, has emerged as a compelling subject of study in cancer treatment. This comprehensive review delves into the significance and originality of quercetin\'s multifaceted mechanisms of action, with a particular focus on its application in various brain tumors such as glioblastoma, glioma, neuroblastoma, astrocytoma, and medulloblastoma. This review scrutinizes the distinctive facets of quercetin\'s anti-cancer properties, highlighting its capacity to modulate intricate signaling pathways, trigger apoptosis, impede cell migration, and enhance radiosensitivity in brain tumor cells. Significantly, it synthesizes recent research findings, providing insights into potential structure-activity relationships that hold promise for developing novel quercetin derivatives with heightened effectiveness. By unraveling the unique attributes of quercetin\'s anti-brain tumor effects and exploring its untapped potential in combination therapies, this review contributes to a deeper comprehension of quercetin\'s role as a prospective candidate for advancing innovative treatments for brain cancer.
摘要：
槲皮素,一种在蔬菜和水果中大量存在的天然多酚化合物，已经成为癌症治疗中一个引人注目的研究对象。这篇全面的综述探讨了槲皮素多方面作用机制的意义和独创性，特别关注其在各种脑肿瘤如胶质母细胞瘤中的应用，神经胶质瘤,神经母细胞瘤,星形细胞瘤,和髓母细胞瘤.这篇综述审查了槲皮素抗癌特性的独特方面，突出了它调节复杂信号通路的能力，触发细胞凋亡，阻碍细胞迁移，增强脑肿瘤细胞的放射敏感性。重要的是,它综合了最近的研究成果，提供潜在的结构-活性关系的见解，为开发具有更高效力的新型槲皮素衍生物提供了希望。通过解开槲皮素抗脑肿瘤作用的独特属性，探索其在联合治疗中尚未开发的潜力，这篇综述有助于更深入地理解槲皮素作为推进脑癌创新治疗的潜在候选药物的作用。
