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Abstract：
Neonatal disorders are facing serious public health challenges. Previous studies were based on limited data sources and had a narrow geographical scope. We aim to understand the trends of alteration in the burden of neonatal disorders from 1990 to 2019 in 204 countries and territories.
Data were investigated from the Global Burden of Disease Study 2019. First, we visualized the burden of neonatal disorders using the number of cases and the age-standardized incidence rate (ASIR), death rate (ASDR), and disability-adjusted life years (ASR-DALYs) from 1990 to 2019. Second, estimated annual percentage changes (EAPCs) were used to evaluate the temporal trends of disease burden during different periods. Finally, the sociodemographic index (SDI) and human development index (HDI) were used to determine whether there exists a correlation between socioeconomic development level, human development level, and potential burden consequences.
Overall, in the past 30 years, the ASIR trends have remained relatively steady, whereas the ASDR and ASR-DALYs have declined. However, the burden of neonatal disorders varied greatly in various regions and countries. Among 21 regions, the ASIR trend had the largest increase in Central Latin America (EAPC = 0.42, 95%CI = 0.33-0.50). Conversely, the ASDR and ASR-DALYs experienced the largest decrease in Central Europe (EAPC = -5.10, 95%CI = -5.28 to 4.93) and East Asia (EAPC = -4.07, 95%CI = -4.41 to 3.73), respectively. Among 204 countries, the ASIR (EAPC = 3.35, 95%CI = 3.13-3.56) trend in Greece displayed the most significant increase, while the ASDR (EAPC = 1.26, 95%CI = 1.01-1.50) and ASR-DALYs (EAPC = 1.26, 95%CI = 1.03-1.49) trends in Dominica experienced the most substantial increase. Furthermore, there was a strong correlation between the EAPCs in ASIR, ASDR, ASR-DALYs, and SDI or HDI in 2019, with some exceptions. In addition, countries with elevated levels of HDI experienced a faster increase in ASDR and ASR-DALYs for neonatal disorders.
Although the burden of neonatal disorders shows a downward trend from 1990 to 2019, it is still not optimistic. It is necessary to implement a multi-pronged approach to reduce the increasing burden of neonatal disorders.
Data were investigated from the Global Burden of Disease Study 2019. First, we visualized the burden of neonatal disorders using the number of cases and the age-standardized incidence rate (ASIR), death rate (ASDR), and disability-adjusted life years (ASR-DALYs) from 1990 to 2019. Second, estimated annual percentage changes (EAPCs) were used to evaluate the temporal trends of disease burden during different periods. Finally, the sociodemographic index (SDI) and human development index (HDI) were used to determine whether there exists a correlation between socioeconomic development level, human development level, and potential burden consequences.
Overall, in the past 30 years, the ASIR trends have remained relatively steady, whereas the ASDR and ASR-DALYs have declined. However, the burden of neonatal disorders varied greatly in various regions and countries. Among 21 regions, the ASIR trend had the largest increase in Central Latin America (EAPC = 0.42, 95%CI = 0.33-0.50). Conversely, the ASDR and ASR-DALYs experienced the largest decrease in Central Europe (EAPC = -5.10, 95%CI = -5.28 to 4.93) and East Asia (EAPC = -4.07, 95%CI = -4.41 to 3.73), respectively. Among 204 countries, the ASIR (EAPC = 3.35, 95%CI = 3.13-3.56) trend in Greece displayed the most significant increase, while the ASDR (EAPC = 1.26, 95%CI = 1.01-1.50) and ASR-DALYs (EAPC = 1.26, 95%CI = 1.03-1.49) trends in Dominica experienced the most substantial increase. Furthermore, there was a strong correlation between the EAPCs in ASIR, ASDR, ASR-DALYs, and SDI or HDI in 2019, with some exceptions. In addition, countries with elevated levels of HDI experienced a faster increase in ASDR and ASR-DALYs for neonatal disorders.
Although the burden of neonatal disorders shows a downward trend from 1990 to 2019, it is still not optimistic. It is necessary to implement a multi-pronged approach to reduce the increasing burden of neonatal disorders.
摘要：
■新生儿疾病正面临严重的公共卫生挑战。以前的研究基于有限的数据源，地理范围狭窄。我们的目标是了解从1990年到2019年，204个国家和地区新生儿疾病负担的变化趋势。
■数据来自2019年全球疾病负担研究。首先,我们使用病例数和年龄标准化发病率（ASIR）可视化新生儿疾病的负担，死亡率（ASDR），和1990年至2019年的残疾调整寿命年(ASR-DALYs)。第二,估计的年度百分比变化（EAPC）用于评估不同时期疾病负担的时间趋势。最后,社会人口指数(SDI)和人类发展指数(HDI)用于确定社会经济发展水平之间是否存在相关性,人类发展水平,和潜在的负担后果。
■总的来说，在过去的30年里，ASIR趋势保持相对稳定，而ASDR和ASR-DALYs有所下降。然而,新生儿疾病的负担在不同地区和国家差异很大。在21个地区中，ASIR趋势在拉丁美洲中部增加最大(EAPC=0.42,95CI=0.33-0.50).相反，ASDR和ASR-DALYs在中欧（EAPC=-5.10，95CI=-5.28至4.93）和东亚（EAPC=-4.07，95CI=-4.41至3.73）下降幅度最大，分别。在204个国家中，希腊的ASIR（EAPC=3.35，95CI=3.13-3.56）趋势显示出最显著的增长，而多米尼加的ASDR(EAPC=1.26,95CI=1.01-1.50)和ASR-DALYs(EAPC=1.26,95CI=1.03-1.49)趋势增长最为显著.此外，ASIR中的EAPC之间有很强的相关性，ASDR,ASR-DALYs,以及2019年的SDI或HDI，但有一些例外。此外,HDI水平升高的国家,新生儿疾病的ASDR和ASR-DALYs增加较快.
■尽管从1990年到2019年，新生儿疾病的负担呈下降趋势，但仍然不容乐观。有必要采取多管齐下的方法来减轻新生儿疾病日益增加的负担。
■数据来自2019年全球疾病负担研究。首先,我们使用病例数和年龄标准化发病率（ASIR）可视化新生儿疾病的负担，死亡率（ASDR），和1990年至2019年的残疾调整寿命年(ASR-DALYs)。第二,估计的年度百分比变化（EAPC）用于评估不同时期疾病负担的时间趋势。最后,社会人口指数(SDI)和人类发展指数(HDI)用于确定社会经济发展水平之间是否存在相关性,人类发展水平,和潜在的负担后果。
■总的来说，在过去的30年里，ASIR趋势保持相对稳定，而ASDR和ASR-DALYs有所下降。然而,新生儿疾病的负担在不同地区和国家差异很大。在21个地区中，ASIR趋势在拉丁美洲中部增加最大(EAPC=0.42,95CI=0.33-0.50).相反，ASDR和ASR-DALYs在中欧（EAPC=-5.10，95CI=-5.28至4.93）和东亚（EAPC=-4.07，95CI=-4.41至3.73）下降幅度最大，分别。在204个国家中，希腊的ASIR（EAPC=3.35，95CI=3.13-3.56）趋势显示出最显著的增长，而多米尼加的ASDR(EAPC=1.26,95CI=1.01-1.50)和ASR-DALYs(EAPC=1.26,95CI=1.03-1.49)趋势增长最为显著.此外，ASIR中的EAPC之间有很强的相关性，ASDR,ASR-DALYs,以及2019年的SDI或HDI，但有一些例外。此外,HDI水平升高的国家,新生儿疾病的ASDR和ASR-DALYs增加较快.
■尽管从1990年到2019年，新生儿疾病的负担呈下降趋势，但仍然不容乐观。有必要采取多管齐下的方法来减轻新生儿疾病日益增加的负担。
