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Abstract：
OBJECTIVE: The incidence of lacrimal gland adenocarcinoma is low. This study was designed to analyze the clinical and prognostic characteristics of lacrimal gland adenocarcinoma.
METHODS: This was a clinical study and literature review; 25 patients diagnosed with lacrimal gland adenocarcinoma by histopathology were enrolled and their medical history data were collected.
RESULTS: The incidence of bone destruction and surrounding tissue invasion was 52% and 44%, respectively. The incidence of distant metastasis of lacrimal gland adenocarcinoma was about 50%. The 5-year overall survival rate of death or metastasis was 33.5%. Age, sex, laterality, tumor size, pathology type, bone destruction, nerve or perineural invasion, invasion of peripheral tissue, T stage, AR, Her-2 and treatment had no significant correlation with lacrimal adenocarcinoma\'s prognosis (P > 0.05), while the higher expression of Ki-67 may have higher risk of death or metastasis (P = 0.020).
CONCLUSIONS: The incidence of bone destruction and distant metastasis of lacrimal adenocarcinoma is high and the imaging examination is necessary to assess the risk of distant metastasis. The 5-year survival rate of death or metastasis is 33.5% and the high expression of Ki-67 predicts poor prognosis of lacrimal adenocarcinoma.
METHODS: This was a clinical study and literature review; 25 patients diagnosed with lacrimal gland adenocarcinoma by histopathology were enrolled and their medical history data were collected.
RESULTS: The incidence of bone destruction and surrounding tissue invasion was 52% and 44%, respectively. The incidence of distant metastasis of lacrimal gland adenocarcinoma was about 50%. The 5-year overall survival rate of death or metastasis was 33.5%. Age, sex, laterality, tumor size, pathology type, bone destruction, nerve or perineural invasion, invasion of peripheral tissue, T stage, AR, Her-2 and treatment had no significant correlation with lacrimal adenocarcinoma\'s prognosis (P > 0.05), while the higher expression of Ki-67 may have higher risk of death or metastasis (P = 0.020).
CONCLUSIONS: The incidence of bone destruction and distant metastasis of lacrimal adenocarcinoma is high and the imaging examination is necessary to assess the risk of distant metastasis. The 5-year survival rate of death or metastasis is 33.5% and the high expression of Ki-67 predicts poor prognosis of lacrimal adenocarcinoma.
摘要：
目的：泪腺腺癌发病率低。本研究旨在分析泪腺腺癌的临床及预后特点。
方法：本研究为临床研究和文献复习，收集25例经组织病理学确诊为泪腺腺癌患者的病史资料。
结果：骨破坏和周围组织浸润的发生率分别为52％和44％，分别。泪腺腺癌远处转移的发生率约为50%。死亡或转移的5年总生存率为33.5％。年龄,性别,偏侧性,肿瘤大小,病理类型,骨破坏,神经或神经侵犯，周围组织的侵入，T级,AR,Her-2、治疗与泪腺腺癌预后无明显相关性(P>0.05),而Ki-67的高表达可能具有较高的死亡或转移风险(P=0.020)。
结论：泪腺腺癌骨破坏和远处转移的发生率较高，需要影像学检查以评估远处转移的风险。死亡或转移的5年生存率为33.5％，Ki-67的高表达预示着泪腺腺癌的预后不良。
方法：本研究为临床研究和文献复习，收集25例经组织病理学确诊为泪腺腺癌患者的病史资料。
结果：骨破坏和周围组织浸润的发生率分别为52％和44％，分别。泪腺腺癌远处转移的发生率约为50%。死亡或转移的5年总生存率为33.5％。年龄,性别,偏侧性,肿瘤大小,病理类型,骨破坏,神经或神经侵犯，周围组织的侵入，T级,AR,Her-2、治疗与泪腺腺癌预后无明显相关性(P>0.05),而Ki-67的高表达可能具有较高的死亡或转移风险(P=0.020)。
结论：泪腺腺癌骨破坏和远处转移的发生率较高，需要影像学检查以评估远处转移的风险。死亡或转移的5年生存率为33.5％，Ki-67的高表达预示着泪腺腺癌的预后不良。
