{Reference Type}: Review
{Title}: The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review.
{Author}: Liu R;Ren T;Li J;Wang N;Xu L;Guo Q;Zhang H;Ma J;
{Journal}: J Cancer Res Clin Oncol
{Volume}: 150
{Issue}: 1
{Year}: 2024 Jan 23
{Factor}: 4.322
{DOI}: 10.1007/s00432-023-05510-7
{Abstract}: <B>OBJECTIVE: </B>The incidence of lacrimal gland adenocarcinoma is low. This study was designed to analyze the clinical and prognostic characteristics of lacrimal gland adenocarcinoma.<BR><B>METHODS: </B>This was a clinical study and literature review; 25 patients diagnosed with lacrimal gland adenocarcinoma by histopathology were enrolled and their medical history data were collected.<BR><B>RESULTS: </B>The incidence of bone destruction and surrounding tissue invasion was 52% and 44%, respectively. The incidence of distant metastasis of lacrimal gland adenocarcinoma was about 50%. The 5-year overall survival rate of death or metastasis was 33.5%. Age, sex, laterality, tumor size, pathology type, bone destruction, nerve or perineural invasion, invasion of peripheral tissue, T stage, AR, Her-2 and treatment had no significant correlation with lacrimal adenocarcinoma's prognosis (P > 0.05), while the higher expression of Ki-67 may have higher risk of death or metastasis (P = 0.020).<BR><B>CONCLUSIONS: </B>The incidence of bone destruction and distant metastasis of lacrimal adenocarcinoma is high and the imaging examination is necessary to assess the risk of distant metastasis. The 5-year survival rate of death or metastasis is 33.5% and the high expression of Ki-67 predicts poor prognosis of lacrimal adenocarcinoma.