PDF(Pubmed)
Abstract：
Oral dryness is among the most common conditions experienced by the elderly. As saliva plays a crucial role in maintaining oral health and overall quality of life, the condition is increasingly taking its toll on a rapidly growing aging population. D-galactose (D-gal) stimulates their formation, which in turn cause oxidative stress and accelerate age-related decline in physical function. In this study, we observed a reduction in salivary secretion and amylase levels in aged rats injected with D-gal, confirming salivary gland dysfunction. Treatment with gemigliptin increased DPP-4 inhibition and GLP-1 levels in the salivary glands of aging rats and reduced the expression of AGEs and receptors for advanced glycation end products (RAGE). This effect was caused by the presence of additional reactive oxygen species (ROS) in the salivary glands of the examined rats. Gemigliptin\'s cytoprotective effect reduced amylase and mucin accumulation and increased AQP5 expression, which are important indicators of salivary gland function. In sum, gemigliptin was shown to improve D-gal-induced decline in the salivary gland function of aged rats through its anti-glycation and antioxidant activities. Gemigliptin shows promise as a treatment strategy for patients experiencing decreased salivary function associated with their advancing age.
摘要：
口腔干燥是老年人最常见的疾病之一。由于唾液在维持口腔健康和整体生活质量方面起着至关重要的作用，这种情况对迅速增长的人口老龄化造成了越来越大的影响。D-半乳糖（D-gal）刺激它们的形成，这反过来又会导致氧化应激并加速与年龄相关的身体功能下降。在这项研究中,我们观察到注射D-gal的老年大鼠唾液分泌和淀粉酶水平降低，确认唾液腺功能障碍。吉格列汀治疗可增加衰老大鼠唾液腺中DPP-4的抑制作用和GLP-1的水平，并降低AGEs和晚期糖基化终产物（RAGE）受体的表达。这种作用是由所检查大鼠的唾液腺中存在额外的活性氧（ROS）引起的。Gemigliptin的细胞保护作用减少淀粉酶和粘蛋白的积累，增加AQP5的表达，是唾液腺功能的重要指标。总之,吉格列汀通过其抗糖基化和抗氧化活性可改善D-gal诱导的老年大鼠唾液腺功能下降。吉格列汀有望作为与年龄增长相关的唾液功能降低的患者的治疗策略。
