PDF(Pubmed)
Abstract：
This study examined the protective effect of flaxseed lignans on liver damage caused by an overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d flaxseed lignan prior to PAM significantly decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBi) levels, while it increased liver superoxide dismutase (SOD) and glutathione (GSH) levels in mice. Flaxseed lignan renovated the gut microbiota dysbiosis induced by PAM by promoting the proliferation of sulfonolipid (SL) producing bacteria such as Alistipes and lignan-deglycosolating bacteria such as Ruminococcus while inhibiting the growth of opportunistic pathogen bacteria such as Acinetobacter and Clostridium. Furthermore, flaxseed lignan modulated the serum metabolomic profile after PAM administration, specifically in the taurine and hypotaurine metabolism, phenylalanine metabolism, and pyrimidine metabolism. The study identified eight potential biomarkers, including enterolactone, cervonyl carnitine, acutilobin, and PC (20:3(5Z, 8Z, 11Z)/20:0). Overall, the results suggest that flaxseed lignan can alleviate PAM-induced hepatotoxicity and may be beneficial in preventing drug-induced microbiome and metabolomic disorders.
摘要：
这项研究检查了亚麻籽木酚素对过量扑热息痛（PAM）引起的肝损伤的保护作用。结果表明，在PAM之前施用800mg/kg/d的亚麻籽木酚能显著降低血清天冬氨酸转氨酶（AST），丙氨酸氨基转移酶（ALT），和总胆红素（TBi）水平，同时增加小鼠肝脏超氧化物歧化酶（SOD）和谷胱甘肽（GSH）水平。亚麻籽木脂素通过促进产生磺酰脂（SL）的细菌（例如Alistipes）和木脂素-去糖细菌（例如Ruminococus）的增殖，同时抑制机会致病菌（例如不动杆菌和梭菌）的生长，从而改善了PAM诱导的肠道微生物群菌群失调。此外，亚麻籽木酚素调节PAM给药后的血清代谢组学，特别是在牛磺酸和次牛磺酸代谢中，苯丙氨酸代谢，和嘧啶代谢。该研究确定了八种潜在的生物标志物，包括肠内酯,cervonyl肉碱,刺血素,和PC(20:3(5Z，8Z,11Z）/20：0）。总的来说,结果表明，亚麻木脂素可以减轻PAM诱导的肝毒性，可能有利于预防药物诱导的微生物组和代谢组学紊乱。
