PDF(Pubmed)
Abstract：
BACKGROUND: Epilepsy is a chronic brain disease affecting millions of people worldwide, but little is known about the impact of anti-seizure medications on redox homeostasis.
METHODS: This study aimed to compare the effects of the long-term use of oral anti-seizure medications in monotherapy (lamotrigine, carbamazepine, and valproate) on antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, haemoglobin, and methaemoglobin content in erythrocytes, and concentrations of total proteins and thiols, nitrites, lipid peroxides and total glutathione in the plasma of epilepsy patients and drug-naïve patients.
RESULTS: The results showed that lamotrigine therapy led to lower superoxide dismutase activity (p < 0.005) and lower concentrations of total thiols (p < 0.01) and lipid peroxides (p < 0.01) compared to controls. On the other hand, therapy with carbamazepine increased nitrite levels (p < 0.01) but reduced superoxide dismutase activity (p < 0.005). In the valproate group, only a decrease in catalase activity was observed (p < 0.005). Canonical discriminant analysis showed that the composition of antioxidant enzymes in erythrocytes was different for both the lamotrigine and carbamazepine groups, while the controls were separated from all others.
CONCLUSIONS: Monotherapy with anti-seizure medications discretely alters redox homeostasis, followed by distinct relationships between antioxidant components.
METHODS: This study aimed to compare the effects of the long-term use of oral anti-seizure medications in monotherapy (lamotrigine, carbamazepine, and valproate) on antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, haemoglobin, and methaemoglobin content in erythrocytes, and concentrations of total proteins and thiols, nitrites, lipid peroxides and total glutathione in the plasma of epilepsy patients and drug-naïve patients.
RESULTS: The results showed that lamotrigine therapy led to lower superoxide dismutase activity (p < 0.005) and lower concentrations of total thiols (p < 0.01) and lipid peroxides (p < 0.01) compared to controls. On the other hand, therapy with carbamazepine increased nitrite levels (p < 0.01) but reduced superoxide dismutase activity (p < 0.005). In the valproate group, only a decrease in catalase activity was observed (p < 0.005). Canonical discriminant analysis showed that the composition of antioxidant enzymes in erythrocytes was different for both the lamotrigine and carbamazepine groups, while the controls were separated from all others.
CONCLUSIONS: Monotherapy with anti-seizure medications discretely alters redox homeostasis, followed by distinct relationships between antioxidant components.
摘要：
背景：癫痫是一种影响全球数百万人的慢性脑部疾病，但对抗癫痫药物对氧化还原稳态的影响知之甚少。
方法：本研究旨在比较长期使用口服抗癫痫药物在单一疗法中的效果（拉莫三嗪，卡马西平,和丙戊酸盐）对抗氧化酶：超氧化物歧化酶，过氧化氢酶,谷胱甘肽过氧化物酶,谷胱甘肽还原酶，血红蛋白，和红细胞中的高铁血红蛋白含量，以及总蛋白质和硫醇的浓度，亚硝酸盐，癫痫患者和未用药患者血浆中的脂质过氧化物和总谷胱甘肽。
结果：结果显示，与对照组相比，拉莫三嗪治疗导致更低的超氧化物歧化酶活性（p<0.005）和更低浓度的总硫醇（p<0.01）和脂质过氧化物（p<0.01）。另一方面,卡马西平治疗增加了亚硝酸盐水平（p<0.01），但降低了超氧化物歧化酶活性（p<0.005）。在丙戊酸盐组中，仅观察到过氧化氢酶活性降低(p<0.005)。典型判别分析显示，拉莫三嗪和卡马西平组的红细胞抗氧化酶组成不同，而对照组与所有其他对照组分开。
结论：抗癫痫药物的单药治疗会离散地改变氧化还原稳态，其次是抗氧化剂成分之间的不同关系。
方法：本研究旨在比较长期使用口服抗癫痫药物在单一疗法中的效果（拉莫三嗪，卡马西平,和丙戊酸盐）对抗氧化酶：超氧化物歧化酶，过氧化氢酶,谷胱甘肽过氧化物酶,谷胱甘肽还原酶，血红蛋白，和红细胞中的高铁血红蛋白含量，以及总蛋白质和硫醇的浓度，亚硝酸盐，癫痫患者和未用药患者血浆中的脂质过氧化物和总谷胱甘肽。
结果：结果显示，与对照组相比，拉莫三嗪治疗导致更低的超氧化物歧化酶活性（p<0.005）和更低浓度的总硫醇（p<0.01）和脂质过氧化物（p<0.01）。另一方面,卡马西平治疗增加了亚硝酸盐水平（p<0.01），但降低了超氧化物歧化酶活性（p<0.005）。在丙戊酸盐组中，仅观察到过氧化氢酶活性降低(p<0.005)。典型判别分析显示，拉莫三嗪和卡马西平组的红细胞抗氧化酶组成不同，而对照组与所有其他对照组分开。
结论：抗癫痫药物的单药治疗会离散地改变氧化还原稳态，其次是抗氧化剂成分之间的不同关系。
