PDF(Pubmed)
Abstract：
Classically, neuropathic pain is described as a pain caused by a lesion or disease of the somatosensory system. However, one must note that the presence of somatosensory pathology alone does not guarantee a progression to neuropathic pain. This is due, in part, to the fact that neuropathic pain is a notoriously complex disease process, involving sensitization of both the central and peripheral nervous systems. Its causes are also numerous and varied, including trauma, the compression of a nerve, autoimmune disorders, diabetes, and infections. Due to the various manifestations, causes, and symptoms of neuropathic pain, the treatment of this disease process has proved challenging for generations of physicians. This section aims to elaborate on newly proposed mechanisms for pharmacological and targeted therapies, such as neurostimulation, which aim to reduce the negative somatosensory effects of neuropathic pain.
摘要：
经典的,神经性疼痛被描述为由体感系统的病变或疾病引起的疼痛。然而,必须注意的是，仅存在体感病理学并不能保证进展为神经性疼痛。这是由于,在某种程度上,事实上，神经性疼痛是一个众所周知的复杂的疾病过程，涉及中枢神经系统和周围神经系统的敏化。其原因也是多种多样的,包括外伤,神经的压迫，自身免疫性疾病，糖尿病,和感染。由于各种表现形式，原因,和神经性疼痛的症状，对于几代医生来说，这种疾病的治疗过程具有挑战性。本节旨在阐述新提出的药理学和靶向治疗机制，比如神经刺激，旨在减少神经性疼痛的负面体感效应。
