PDF(Pubmed)
Abstract：
In pediatric care, the range of potential diagnoses for arthritis can be relatively extensive, primarily involving infectious and inflammatory causes and, to a lesser extent, oncological conditions. Specifically, when addressing inflammatory causes, differentiating between Juvenile Idiopathic Arthritis (JIA) and Reactive Arthritis (ReA) can prove to be challenging during the first weeks, owing to the lack of specific antibodies in several JIA subtypes. This single-center retrospective study of 108 children with arthritis aimed to evaluate in greater detail the complete blood count (CBC) profiles of children with JIA and ReA in greater detail. The most significant differences were noted in terms of the Systemic Immune-Inflammation Index (SII), with higher values in the JIA group. Moreover, within the JIA group, SII displayed a significant positive correlation with conventional inflammatory biomarkers, specifically C-reactive protein (ρ = 0.579) and Erythrocyte Sedimentation Rate (ρ = 0.430). It was the only independent factor associated with the presence of JIA after adjusting for age (p = 0.030). Also, even with the moderate diagnostic value, the discriminating capacity of SII was superior to those of each of its component CBC parameters according to receiver operating characteristic (ROC) analysis. In summary, this study identified elevated SII values in the JIA group compared to the ReA group, indicating the potential utility of SII as an adjuvant discriminatory marker between these two arthritis forms.
摘要：
在儿科护理中，关节炎的潜在诊断范围可能相对广泛，主要涉及感染和炎症原因，在较小程度上，肿瘤条件。具体来说,当解决炎症原因时，在最初几周内，区分幼年特发性关节炎（JIA）和反应性关节炎（ReA）可能具有挑战性，由于几种JIA亚型缺乏特异性抗体。这项针对108名关节炎儿童的单中心回顾性研究旨在更详细地评估JIA和ReA儿童的全血细胞计数（CBC）特征。最显著的差异是在全身免疫炎症指数(SII)方面。JIA组中的值较高。此外，在JIA集团内部，SII与常规炎症生物标志物呈显著正相关,特别是C反应蛋白（ρ=0.579）和红细胞沉降率（ρ=0.430）。这是调整年龄后与JIA存在相关的唯一独立因素(p=0.030)。此外，即使具有中等的诊断价值，根据受试者工作特性（ROC）分析，SII的辨别能力优于其每个分量CBC参数的辨别能力。总之,这项研究发现，与ReA组相比，JIA组的SII值升高，表明SII作为这两种关节炎形式之间的佐剂区分标记的潜在效用。
