PDF(Pubmed)
Abstract：
Chronic itch is a debilitating condition with limited treatment options, severely affecting quality of life. The identification of pruriceptors has sparked a growing interest in the therapeutic potential of TRP channels in the context of itch. In this regard, we provided a comprehensive overview of the site-specific expression of TRP channels and their associated functions in response to a range of pruritogens. Although several potent antipruritic compounds that target specific TRP channels have been developed and have demonstrated efficacy in various chronic itch conditions through experimental means, a more thorough understanding of the potential for adverse effects or interactions with other TRP channels or GPCRs is necessary to develop novel and selective therapeutics that target TRP channels for treating chronic itch. This review focuses on the mechanism of itch associated with TRP channels at specific sites, from the skin to the sensory neuron, with the aim of suggesting specific therapeutic targets for treating this condition.
摘要：
慢性瘙痒是一种令人衰弱的疾病，治疗选择有限，严重影响生活质量。瘙痒感受器的鉴定引发了人们对TRP通道在瘙痒背景下的治疗潜力的日益增长的兴趣。在这方面,我们全面概述了TRP通道的位点特异性表达及其响应一系列致敏剂的相关功能.尽管已经开发了几种针对特定TRP通道的有效止痒化合物，并通过实验手段证明了其在各种慢性瘙痒疾病中的功效，对于开发靶向TRP通道治疗慢性瘙痒的新型选择性疗法,需要更透彻地了解与其他TRP通道或GPCRs的副作用或相互作用的可能性.这篇综述集中在特定部位与TRP通道相关的瘙痒机制，从皮肤到感觉神经元，目的是提出治疗这种疾病的具体治疗靶点。
