Abstract：
The new Japanese diagnostic criteria for obstetrical disseminated intravascular coagulation (DIC) (tentative version) were released in June 2022. We aimed to demonstrate the differences in characteristics between women with DIC diagnosed using the new Japanese criteria and those diagnosed using the pregnancy-specific modified International Society on Thrombosis and Hemostasis DIC score, also known as the pregnancy-specific modified ISTH DIC score, which was released in 2014. In this retrospective cohort study, all participants were retrospectively diagnosed based on both criteria. Six women were diagnosed with obstetrical DIC based on both criteria (Group A). Of the 43 women diagnosed with obstetrical DIC based on the worldwide criteria, 36 were diagnosed with non-obstetrical DIC based on the new Japanese criteria (Group B). Group A had significantly lower fibrinogen levels and significantly higher prothrombin time differences and scores of underlying diseases (particularly postpartum hemorrhage with coagulopathy) and laboratory findings than Group B. Additionally, Group A had significantly higher rates of platelet concentrate (PC) transfusion therapy for obstetrical DIC and more transfusions of fresh frozen plasma and/or cryoprecipitate, red blood cells and PC than Group B. Thus, the new Japanese criteria detected more severe cases of obstetrical DIC compared with the worldwide criteria.
摘要：
日本新的产科弥散性血管内凝血（DIC）诊断标准（暂定版本）已于2022年6月发布。我们旨在证明使用新的日本标准诊断的DIC女性与使用妊娠特异性改良的国际血栓和止血学会DIC评分诊断的女性之间的特征差异。也称为妊娠特异性改良ISTHDIC评分，于2014年发布。在这项回顾性队列研究中，所有参与者均根据两项标准进行回顾性诊断.根据这两个标准，六名妇女被诊断为产科DIC（A组）。在根据全球标准诊断为产科DIC的43名妇女中，36例根据新的日本标准诊断为非产科DIC（B组）。与B组相比，A组的纤维蛋白原水平显着降低，凝血酶原时间差异和基础疾病评分（尤其是产后出血伴凝血功能障碍）和实验室检查结果显着升高。A组有明显更高的血小板浓缩物（PC）输血治疗产科DIC和更多的新鲜冷冻血浆和/或冷沉淀的输血率，红细胞和PC比B组。因此，与全球标准相比,新的日本标准检测出更严重的产科DIC病例.
