PDF(Pubmed)
Abstract：
This comprehensive review delves into cancer\'s complexity, focusing on adhesion, metastasis, and inhibition. It explores the pivotal role of these factors in disease progression and therapeutic strategies. This review covers cancer cell migration, invasion, and colonization of distant organs, emphasizing the significance of cell adhesion and the intricate metastasis process. Inhibition approaches targeting adhesion molecules, such as integrins and cadherins, are discussed. Overall, this review contributes significantly to advancing cancer research and developing targeted therapies, holding promise for improving patient outcomes worldwide. Exploring different inhibition strategies revealed promising therapeutic targets to alleviate adhesion and metastasis of cancer cells. The effectiveness of integrin-blocking antibodies, small molecule inhibitors targeting Focal adhesion kinase (FAK) and the Transforming Growth Factor β (TGF-β) pathway, and combination therapies underscores their potential to disrupt focal adhesions and control epithelial-mesenchymal transition processes. The identification of as FAK, Src, β-catenin and SMAD4 offers valuable starting points for further research and the development of targeted therapies. The complex interrelationships between adhesion and metastatic signaling networks will be relevant to the development of new treatment approaches.
摘要：
这篇全面的综述深入探讨了癌症的复杂性，专注于附着力，转移,和抑制。它探讨了这些因素在疾病进展和治疗策略中的关键作用。这篇综述涵盖了癌细胞迁移，入侵,和远处器官的定殖，强调细胞粘附的重要性和复杂的转移过程。靶向粘附分子的抑制方法，如整合素和钙粘蛋白，正在讨论。总的来说,这篇综述大大有助于推进癌症研究和开发靶向治疗，有望改善全球患者的治疗效果。探索不同的抑制策略揭示了有希望的治疗靶标，以减轻癌细胞的粘附和转移。整合素阻断抗体的有效性，靶向粘着斑激酶（FAK）和转化生长因子β（TGF-β）途径的小分子抑制剂，和联合疗法强调了它们破坏局灶性粘连和控制上皮-间质转化过程的潜力。作为FAK的识别，Src,β-catenin和SMAD4为进一步研究和靶向治疗的开发提供了有价值的起点。粘附和转移信号网络之间复杂的相互关系将与新治疗方法的发展有关。
