PDF(Pubmed)
Abstract：
In tropical areas, the simultaneous transmission of multiple vector-borne diseases is common due to ecological factors shared by arthropod vectors. Malaria and dengue virus, transmitted by Anopheles and Aedes mosquitoes, respectively, are among the top vector-borne diseases that cause significant morbidity and mortality in endemic areas. Notably, tropical areas often have suitable conditions for the co-existence of these mosquito species, highlighting the importance of identifying markers that accurately indicate the risk of acquiring each specific disease entity. Aedes are daytime-biting mosquitoes, while Anopheles preferentially bite during the night. These biting patterns raise the possibility of concurrent exposure to bites from both species. This is important because mosquito saliva, deposited in the skin during blood feeding, induces immune responses that modulate pathogen establishment and infection. Previous studies have focused on characterizing such effects on the vector-pathogen interface for an individual pathogen and its mosquito vector. In this study, we evaluated associations between immune responses to salivary proteins from non-dengue and non-malaria vector mosquito species with clinical characteristics of malaria and dengue, respectively. Surprisingly, antibody responses against Anopheles antigens in dengue patients correlated with red blood cell count and hematocrit, while antibody responses against Aedes proteins were associated with platelet count in malaria patients. Our data indicate that concurrent exposure to multiple disease-carrying mosquito vectors and their salivary proteins with differing immunomodulatory properties could influence the transmission, pathogenesis, and clinical presentation of malaria, dengue fever, and other vector-borne illnesses.
摘要：
在热带地区,由于节肢动物媒介共有的生态因素，多种媒介传播疾病的同时传播很常见。疟疾和登革热病毒，由按蚊和伊蚊传播，分别,是导致流行地区发病率和死亡率最高的媒介传播疾病之一。值得注意的是,热带地区通常有适合这些蚊子共存的条件，强调识别准确指示获得每种特定疾病实体的风险的标记的重要性。伊蚊是白天叮咬的蚊子，而按蚊则在夜间优先咬人。这些叮咬模式增加了同时暴露于两个物种叮咬的可能性。这很重要，因为蚊子的唾液，在血液喂养过程中沉积在皮肤中，诱导调节病原体建立和感染的免疫反应。先前的研究集中在表征对个体病原体及其蚊子媒介的媒介-病原体界面的这种影响。在这项研究中,我们评估了非登革热和非疟疾媒介蚊子对唾液蛋白的免疫反应与疟疾和登革热的临床特征之间的关联，分别。令人惊讶的是,登革热患者针对按蚊抗原的抗体反应与红细胞计数和血细胞比容相关，而针对伊蚊蛋白的抗体反应与疟疾患者的血小板计数相关。我们的数据表明，同时暴露于多种携带疾病的蚊子载体及其具有不同免疫调节特性的唾液蛋白可能会影响传播，发病机制，和疟疾的临床表现，登革热,和其他媒介传播的疾病。
