PDF(Pubmed)
Abstract：
Real-world data indicated that some endometrial atypical hyperplasia (EAH) and early endometrial carcinoma (EEC) patients of fertility preservation had a normal ovarian reserve, while some had a decreased ovarian reserve (DOR). This study was designed to investigate the effect of baseline ovarian reserve on the treatment of EAH and EEC patients who ask for preservation of fertility.
This was a prospective cohort study conducted at a single university-affiliated fertility center. A total of 102 EAH and EEC patients who received fertility-preserving treatment between March 2019 and August 2020 were included and divided into a DOR group (n=22) and a non-DOR group (n=80).
The 32-week CR rate of the non-DOR group was significantly higher than that of the DOR group (60.3% vs. 33.3%, P =0.028). The DOR group had a longer treatment duration to achieve CR than the non-DOR group (40.07 vs. 29.71 weeks, P=0.008, HR: 0.54, 95% CI: 0.36-0.86). Multivariate logistic regression analyses demonstrated that DOR (OR: 0.35, 95% CI: 0.13-0.99, P=0.049) and BMI ≥25 kg/m2 (OR: 0.40, 95% CI: 0.17-0.92, P=0.031) were negatively associated with 32-week CR.
Decreased baseline ovarian reserve is negatively correlated with the efficacy of fertility-preserving treatment in EAH and EEC patients, as this group has a lower CR rate and a longer treatment duration to achieve CR than those without DOR.
This was a prospective cohort study conducted at a single university-affiliated fertility center. A total of 102 EAH and EEC patients who received fertility-preserving treatment between March 2019 and August 2020 were included and divided into a DOR group (n=22) and a non-DOR group (n=80).
The 32-week CR rate of the non-DOR group was significantly higher than that of the DOR group (60.3% vs. 33.3%, P =0.028). The DOR group had a longer treatment duration to achieve CR than the non-DOR group (40.07 vs. 29.71 weeks, P=0.008, HR: 0.54, 95% CI: 0.36-0.86). Multivariate logistic regression analyses demonstrated that DOR (OR: 0.35, 95% CI: 0.13-0.99, P=0.049) and BMI ≥25 kg/m2 (OR: 0.40, 95% CI: 0.17-0.92, P=0.031) were negatively associated with 32-week CR.
Decreased baseline ovarian reserve is negatively correlated with the efficacy of fertility-preserving treatment in EAH and EEC patients, as this group has a lower CR rate and a longer treatment duration to achieve CR than those without DOR.
摘要：
■现实世界数据表明，一些子宫内膜非典型增生（EAH）和早期子宫内膜癌（EEC）保留生育能力的患者卵巢储备正常，而一些卵巢储备（DOR）下降。这项研究旨在研究基线卵巢储备对要求保留生育能力的EAH和EEC患者治疗的影响。
■这是一项在一所大学附属生育中心进行的前瞻性队列研究。共有102例EAH和EEC患者在2019年3月至2020年8月期间接受了保留生育能力的治疗，并分为DOR组（n=22）和非DOR组（n=80）。
■非DOR组的32周CR率显着高于DOR组（60.3％vs.33.3%,P=0.028)。DOR组比非DOR组有更长的治疗时间达到CR（40.07vs.29.71周，P=0.008,HR:0.54,95%CI:0.36-0.86)。多因素logistic回归分析显示，DOR（OR：0.35，95％CI：0.13-0.99，P=0.049）和BMI≥25kg/m2（OR：0.40，95％CI：0.17-0.92，P=0.031）与32周CR呈负相关。
■在EAH和EEC患者中，基线卵巢储备减少与保留生育治疗的疗效呈负相关，与没有DOR的患者相比，该组的CR率更低，达到CR的治疗持续时间更长。
■这是一项在一所大学附属生育中心进行的前瞻性队列研究。共有102例EAH和EEC患者在2019年3月至2020年8月期间接受了保留生育能力的治疗，并分为DOR组（n=22）和非DOR组（n=80）。
■非DOR组的32周CR率显着高于DOR组（60.3％vs.33.3%,P=0.028)。DOR组比非DOR组有更长的治疗时间达到CR（40.07vs.29.71周，P=0.008,HR:0.54,95%CI:0.36-0.86)。多因素logistic回归分析显示，DOR（OR：0.35，95％CI：0.13-0.99，P=0.049）和BMI≥25kg/m2（OR：0.40，95％CI：0.17-0.92，P=0.031）与32周CR呈负相关。
■在EAH和EEC患者中，基线卵巢储备减少与保留生育治疗的疗效呈负相关，与没有DOR的患者相比，该组的CR率更低，达到CR的治疗持续时间更长。
