This was a prospective cohort study conducted at a single university-affiliated fertility center. A total of 102 EAH and EEC patients who received fertility-preserving treatment between March 2019 and August 2020 were included and divided into a DOR group (n=22) and a non-DOR group (n=80).
The 32-week CR rate of the non-DOR group was significantly higher than that of the DOR group (60.3% vs. 33.3%, P =0.028). The DOR group had a longer treatment duration to achieve CR than the non-DOR group (40.07 vs. 29.71 weeks, P=0.008, HR: 0.54, 95% CI: 0.36-0.86). Multivariate logistic regression analyses demonstrated that DOR (OR: 0.35, 95% CI: 0.13-0.99, P=0.049) and BMI ≥25 kg/m2 (OR: 0.40, 95% CI: 0.17-0.92, P=0.031) were negatively associated with 32-week CR.
Decreased baseline ovarian reserve is negatively correlated with the efficacy of fertility-preserving treatment in EAH and EEC patients, as this group has a lower CR rate and a longer treatment duration to achieve CR than those without DOR.
■这是一项在一所大学附属生育中心进行的前瞻性队列研究。共有102例EAH和EEC患者在2019年3月至2020年8月期间接受了保留生育能力的治疗,并分为DOR组(n=22)和非DOR组(n=80)。
■非DOR组的32周CR率显着高于DOR组(60.3%vs.33.3%,P=0.028)。DOR组比非DOR组有更长的治疗时间达到CR(40.07vs.29.71周,P=0.008,HR:0.54,95%CI:0.36-0.86)。多因素logistic回归分析显示,DOR(OR:0.35,95%CI:0.13-0.99,P=0.049)和BMI≥25kg/m2(OR:0.40,95%CI:0.17-0.92,P=0.031)与32周CR呈负相关。
■在EAH和EEC患者中,基线卵巢储备减少与保留生育治疗的疗效呈负相关,与没有DOR的患者相比,该组的CR率更低,达到CR的治疗持续时间更长。