关键词: Aspergillus central nervous system fungal infections fungal meningitis immunocompetence invasive fungal infections myelitis

Mesh : Humans Male Middle Aged Myelitis / microbiology Aspergillus fumigatus / isolation & purification Immunocompetence Magnetic Resonance Imaging Neuroaspergillosis Aspergillosis / complications diagnosis Antifungal Agents / therapeutic use

来  源:   DOI:10.1177/13524585231221680

Abstract:
UNASSIGNED: Fungal infections of the central nervous system usually affect immunocompromised patients. Primary Aspergillus myelitis has never been described.
UNASSIGNED: A 45-year-old immunocompetent male with subacute paraplegia was treated for inflammatory myelitis before clinical deterioration requiring mechanical ventilation. Purulent meningitis preceded the formation of a paraspinal nodule biopsied by neurosurgery. Histopathological analysis revealed the presence of fungal hyphae, and polymerase chain reaction was positive for Aspergillus fumigatus. No cause of immunodeficiency was identified in this patient.
UNASSIGNED: Primary Aspergillus myelitis may be confused with inflammatory myelitis and should be considered even in the absence of apparent immunosuppression.
摘要:
中枢神经系统的真菌感染通常会影响免疫功能低下的患者。原发性曲霉脊髓炎从未被描述过。
一名45岁免疫功能正常的亚急性截瘫男性在临床恶化之前需要机械通气治疗炎症性脊髓炎。化脓性脑膜炎先于神经外科活检的椎旁结节形成。组织病理学分析显示真菌菌丝的存在,和聚合酶链反应阳性的烟曲霉。在该患者中未发现免疫缺陷的原因。
原发性曲霉性脊髓炎可能与炎性脊髓炎混淆,即使没有明显的免疫抑制也应考虑。
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