PDF(Pubmed)
Abstract：
This article provides recommendations for implementing QSM for clinical brain research. It is a consensus of the International Society of Magnetic Resonance in Medicine, Electro-Magnetic Tissue Properties Study Group. While QSM technical development continues to advance rapidly, the current QSM methods have been demonstrated to be repeatable and reproducible for generating quantitative tissue magnetic susceptibility maps in the brain. However, the many QSM approaches available have generated a need in the neuroimaging community for guidelines on implementation. This article outlines considerations and implementation recommendations for QSM data acquisition, processing, analysis, and publication. We recommend that data be acquired using a monopolar 3D multi-echo gradient echo (GRE) sequence and that phase images be saved and exported in Digital Imaging and Communications in Medicine (DICOM) format and unwrapped using an exact unwrapping approach. Multi-echo images should be combined before background field removal, and a brain mask created using a brain extraction tool with the incorporation of phase-quality-based masking. Background fields within the brain mask should be removed using a technique based on SHARP or PDF, and the optimization approach to dipole inversion should be employed with a sparsity-based regularization. Susceptibility values should be measured relative to a specified reference, including the common reference region of the whole brain as a region of interest in the analysis. The minimum acquisition and processing details required when reporting QSM results are also provided. These recommendations should facilitate clinical QSM research and promote harmonized data acquisition, analysis, and reporting.
摘要：
本文为临床脑研究实施QSM提供了建议。这是国际医学磁共振学会的共识，电磁组织特性研究组。在QSM技术持续快速发展的同时，目前的QSM方法已被证明是可重复和可重复的，可用于生成大脑中的定量组织磁化率图。然而,现有的许多QSM方法在神经影像学界产生了对实施指南的需求.本文概述了QSM数据采集的注意事项和实施建议，processing,分析,和出版。我们建议使用单极3D多回波梯度回波（GRE）序列获取数据，并以医学数字成像和通信（DICOM）格式保存和导出相位图像，并使用精确展开方法展开。多回波图像应在背景场去除之前进行组合，以及使用大脑提取工具创建的大脑掩模，并结合了基于相位质量的掩模。应使用基于SHARP或PDF的技术删除大脑掩模中的背景字段，偶极子反演的优化方法应该采用基于稀疏性的正则化。磁化率值应相对于指定的参考进行测量，包括整个大脑的共同参考区域作为分析中的感兴趣区域。还提供了报告QSM结果所需的最低采集和处理细节。这些建议应促进临床QSM研究并促进统一的数据采集，分析,和报告。
